1. bookVolume 12 (2019): Issue 4 (December 2019)
Journal Details
License
Format
Journal
First Published
19 Jun 2009
Publication timeframe
4 times per year
Languages
English
access type Open Access

Effect of tramadol dependence on male sexual dysfunction

Published Online: 30 Apr 2020
Page range: 157 - 162
Received: 16 Jun 2017
Accepted: 17 Mar 2018
Journal Details
License
Format
Journal
First Published
19 Jun 2009
Publication timeframe
4 times per year
Languages
English
Abstract

Tramadol dependence became an increasing and alarming problem in the Egyptian community. Wide availability of tramadol as a pain killer and its role in the treatment of premature ejaculation may be the most apparent causes of increased magnitude of the problem among youth who believe that tramadol has a positive impact on their sexual functions. This study aimed to explore the real impact of chronic tramadol administration on sexual functions in males dependent on tramadol. The study was carried on 80 subjects (50 subjects were tramadol dependent group and 30 subjects represented the control group). Personal, family and past histories were obtained from all the participants in addition to the toxicological history from tramadol dependent group. Urine screening for tramadol was done for all cases of history of tramadol dependence then confirmation by HPLC technique to measure tramadol blood level was done. Both groups were investigated for serum testosterone and prolactin level. Curiosity (22%) and treatment of premature ejaculation (20%) were the main motives for dependence. Erectile dysfunction and decreased libido occurred in 44% and 48% of tramadol dependent group respectively. Significant increase in erectile dysfunction and decreased libido was noted as the duration of dependence increased. Additionally, significant decrease in serum testosterone level and increase in serum prolactin level as tramadol daily dose and duration increased was found. In conclusion, men who take tramadol for premature ejaculation or any other purpose must know that they are very susceptible to many sexual dysfunctions.

Keywords

Abou Eleinen R, Amr M, El-Gilany A, El-Mogy A, Fathi W.(2014). Substance abuse and dependence among patients attending Mansoura emergency hospital in eastern Nile delta, Egypt. Journal of Psychiatry17: 532–537.Search in Google Scholar

Adams EH, Breine S, Cicero TJ, Geller A. (2006). A comparison of abuse liability of tramadol, NSAIDs, and hydrocodone in patients with chronic pain. J Pain Symptom Manage31(5): 465–476.Search in Google Scholar

American Psychiatric Association (APA) (2013). Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V). Washington, DC: American Psychiatric Publishing, Inc. [Last accessed on 2013, Jul 1]. Available from: http://www.psychiatry.org/practice/dsm/dsm-history-of-the-manual.Search in Google Scholar

Atici S, Cinel I, Cinel L. (2005). Liver and kidney toxicity in chronic use of opioids: An experimental long term treatment model. J. Biosci5(13): 30245–30252.Search in Google Scholar

Auernhammer CJ, Renner U, Muller OA. (1993). Loperamide inhibits corticotrophic cell function by a naloxone-insensitive mechanism in the rat in vitro. Neuroendocrinology57(6): 1019–1027.Search in Google Scholar

Chan S, Debono M, Rolfe C. (2011). Tramadol-induced Adrenal Insufficiency. Endocrine Abstracts25: 84.Search in Google Scholar

Bassiony M. (2013). Substance use disorders in Saudi Arabia. J Subst Use9(6): 450–466.Search in Google Scholar

Daniell HW. (2002). Hypogonadism in men consuming sustained-action oral opioids. J Pain3(5): 377–384Search in Google Scholar

Das G. (2014). Chronic Heroin Dependence Leading to Adrenal Insufficiency. Case Rep Endocrinol4(6): 181–183.Search in Google Scholar

De Micheli D, Lucia M, Formigoni OS. (2002). Are reasons for the first use of drugs and family circumstances predictors of future use patterns? Addict Behave27(1): 87–100.Search in Google Scholar

Deer TR, Gunn J. (2015). Blood testing in chronic pain management. Pain Physician18(2): 157–161.Search in Google Scholar

Deering D, Sellman D, Adamson S, Campbell S, Sheridan J, Pooley S, Robertson R, Henderson C. (2008). Opioid Dependence in New Zealand – A report for the Ministry of Health. National Addiction Centre, Otago University.Search in Google Scholar

Eassa BI, El-Shazly MA. (2012). Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation. Asian J Androl3: 12–14.Search in Google Scholar

El-Gaafarawi II. (2006). Biochemical Toxicity Induced By Tramadol Administration In Male Rats. EJHM23: 353–362.Search in Google Scholar

El-Ghawet H. (2015). Effects of tramadol on the reproductive function of wi-star albino rats, Zoology Dept, Faculty of Science, Mansoura University, Egypt. Eur J Exp Biol5(1): 56–64.Search in Google Scholar

Feldman HA, Goldstein I, Hatzichristou DG. (1994). Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol151: 54–61.Search in Google Scholar

Frantz AG, Kleinberg DL, Noel GL. (1997). Studies on prolactin in man. Recent Prog Horm Res6: 527–528.Search in Google Scholar

Geng-Chang Y, Ming-Thau S, Chia-Lin Y, Ya-Wen W, Cheng-Hsiung L. (1999). High-performance liquid chromatographic method for determination of tramadol in human plasma. J Chromatogr723: 247–253.Search in Google Scholar

Goda AS. (2013). Study of oxidative factors and DNA damage in tramadol addicts. M.D Thesis (clin. Toxicology). Faculty of medicine, Cairo University. Egypt.Search in Google Scholar

Goodyear-Smith F, Gohns A, Butler R, Sheridan J, Wheeler A. (2008). Metha-done Maintenance Treatment: Barriers to, and incentives for, the transfer of opioid dependent people from secondary care to primary health care. Drug Alcohol Rev27(2): 178–184.Search in Google Scholar

Gowing LR, Ali RL, White JM. (2000). Management of opioid withdrawal. Aust N Z J Public Health24(4): 427–431.Search in Google Scholar

Hamdi E, Gawad T, Khoweiled A. (2013). Lifetime Prevalence of Alcohol and Substance Use in Egypt: A Community Survey. Substance Abuse34(2): 97–104.Search in Google Scholar

Hatzimouratidis K. (2007). Epidemiology of male sexual dysfunction. Am J Mens Health1(2): 103–25.Search in Google Scholar

Herzog AG, Drislane FW, Schomer DL, Pennell PB. (2004). Differntial effects of tramadol on sexual function and reproductive hormones in men. Horm. Behav45(7): 764–768.Search in Google Scholar

International Narcotics Control Board Report (INCB). (2013). Analysis Of The World Situation. United Nations Publication. ch 3. (www.incb.org).Search in Google Scholar

Kaminetsky J. (2008). Epidemiology and pathophysiology of male sexual dysfunction. Int J Impot Res20: S3–S10.Search in Google Scholar

Katz M, Nathaniel D, Mazer M, Norman A. (2009). The Impact of Opioids on the Endocrine System. Clin. J. Pain25(2): 170–175.Search in Google Scholar

Marquardt KA, Alsopm JA, Albertson TE. (2005). Tramadol exposures reported to statewide poison control system. Ann. Pharmacother.J39(6): 1039–1044.Search in Google Scholar

Mc Elhaney KB, Antonishak J, Allen JP. (2008). They like me, they like me not: Popularity and adolescents’ perceptions of acceptance predicting social functioning over time. Child Dev79(3): 720–731.Search in Google Scholar

Mckim WA. (2003). Drug and behavior, an introduction to behavioral pharmacology. Prentice Hall, New Jersey, 5th ed., p.243.Search in Google Scholar

Monahan K, Egan EA, Van Horn M. (2011). Community-level effects of individual and peer risk and protective factors on adolescent substance use. J Community Psychol39(4): 478–498.Search in Google Scholar

Nicolosi A, Laumann EO, Glasser DB, Moreira ED, Paik A, Gingell C. (2004). Sexual behavior and sexual dysfunctions after age 40: the global study of sexual attitudes and behaviors. Urology64: 991–997.Search in Google Scholar

Rebecca E, Schane RE, Pamela M, Ling PM, Stanto A, Glant SA. (2010). Health Effects of Light and Intermittent Smoking. Am Heart Assoc121: 1518–1522.Search in Google Scholar

Oshodi OY, Aina OF, Onajole AT. (2010). Substance use among secondary school students in an urban setting in Nigeria: prevalence and associated factors. Afr J Psychiatry13: 52–57.Search in Google Scholar

Salem EA, Wilson SK, Bissada NK, Delk JR, Hellstrom WJ, Cleve MA. (2008). Tramadol HCL has promise in on-demand use to treat premature ejaculation. J Sex Med5: 188–193.Search in Google Scholar

Shipton EA. (2000). Tramadol-present and future. Anaesthesia. Intensive Care28(4): 363–374.Search in Google Scholar

Solarino B, Riesselmann B, Buschmann CT, Sokos M. (2010). Multidrug poisoning involving nicotine and tramadol. Forensic Sci. Int194(1–3): 17–19.Search in Google Scholar

Tashakori A, Afshari R. (2010). Tramadol overdose as a cause of serotonin syndrome: a case series. Clin Toxicol48(4): 337–341.Search in Google Scholar

Travison TG, Araujo AB, O〉Donnell AB, Kupelian V, McKinlay JB. (2007). A population-level decline in serum testosterone levels in men. J Clin Endocrinol Metab92(1): 196–202.Search in Google Scholar

Vorsanger GJ, Xiang J, Gana TJ, Pascua ML, Fleming R. (2008). Extended-release tramadol (tramadol ER) in the treatment of chronic low back pain. J Opioid Manag4(2): 87–97.Search in Google Scholar

Recommended articles from Trend MD

Plan your remote conference with Sciendo