<abstract xmlns="http://www.w3.org/1999/xhtml"><p> A number of seaweed species are used as traditional foods and medicine in different parts of the world, including Asian countries. However, very few data on the anti-melanogenic effect of seaweed have been published. Undaria pinnatifida (Dolmiyeok), a brown alga, is a traditional food in Jeju Island, the southern regions of the Korea peninsula. In this study, ethylacetate extracts of U. pinnatifida (UPE) were examined for their anti-melanogenic potentials. Our results supports the finding that UPE down-regulated melanin content in a dose-dependent pattern. To clarify the target of UPE action in melanogenesis, we performed Western blotting for tyrosinase and microphthalmia-associated transcription factor (MITF), which are key melanogenic enzymes. UPE inhibited tyrosinase and MITF expressions in a dose-dependent manner. These results indicate that treatment with UPE significantly inhibits the melanogenesis in B16 cells, and may be effective in the whitening agent for the skin</p></abstract>

A number of seaweed species are used as traditional foods and medicine in different parts of the world, including Asian countries. However, very few data on the anti-melanogenic effect of seaweed have been published. Undaria pinnatifida (Dolmiyeok), a brown alga, is a traditional food in Jeju Island, the southern regions of the Korea peninsula. In this study, ethylacetate extracts of U. pinnatifida (UPE) were examined for their anti-melanogenic potentials. Our results supports the finding that UPE down-regulated melanin content in a dose-dependent pattern. To clarify the target of UPE action in melanogenesis, we performed Western blotting for tyrosinase and microphthalmia-associated transcription factor (MITF), which are key melanogenic enzymes. UPE inhibited tyrosinase and MITF expressions in a dose-dependent manner. These results indicate that treatment with UPE significantly inhibits the melanogenesis in B16 cells, and may be effective in the whitening agent for the skin

Melanogenesis inhibitory activity of Korean Undaria pinnatifida in mouse B16 melanoma cells

Jeju Biodiversity Research Institute (JBRI), Jeju Technopark, Jeju 699-943, Korea

Cosmetic Science Center, Faculty of Chemistry and Cosmetics, Jeju National University, Jeju 690-756, Korea

Jeju Biodiversity Research Institute (JBRI), Jeju Technopark, Jeju 699-943, Korea / Cosmetic Science Center, Faculty of Chemistry and Cosmetics, Jeju National University, Jeju 690-756, Korea

Interdisciplinary Toxicology

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A number of seaweed species are used as traditional foods and medicine in different parts of the world, including Asian countries. However, very few data on...

Melanogenesis inhibitory activity of Korean Undaria pinnatifida in mouse B16 melanoma cells

Published Online: Nov 15, 2014

Page range: 89 - 92

Received: Apr 23, 2013

Accepted: Apr 02, 2014

DOI: https://doi.org/10.2478/intox-2014-0012

© Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.