<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>In recent decades, chronic viral infection C (HCV) has posed a major public health challenge globally, considering the morbidity and mortality associated with this condition, as well as the difficulties related to diagnosis and treatment. Recently, significant advances in medical and pharmaceutical research have led to the development of new direct-acting antiviral therapies (DAAs), marking the beginning of a new era in HCV treatment. These treatments promise cure rates of over 90%, an improved safety profile, and a reduced duration of therapy compared to previous interferon-based regimens. This article aims to examine the evolution of HCV treatment, with a special focus on recent innovations in antiviral therapy. We will analyze the mechanisms of action of DAAs, their efficacy and safety, and their impact on populations with limited access to treatment. Additionally, we discuss the remaining challenges in the path to HCV eradication, including late diagnosis, barriers to treatment access, and the need for long-term monitoring of cured patients. By consolidating data from recent clinical studies and reviewing the specialized literature, this article provides a comprehensive perspective on the current landscape of HCV treatment, highlighting significant progress made and underlining the future directions needed to address remaining challenges. Finally, we reaffirm the importance of an integrated approach, encompassing prevention, early diagnosis, and universal access to innovative treatments, as a cornerstone in the fight against HCV.</p>
</abstract>

In recent decades, chronic viral infection C (HCV) has posed a major public health challenge globally, considering the morbidity and mortality associated with this condition, as well as the difficulties related to diagnosis and treatment. Recently, significant advances in medical and pharmaceutical research have led to the development of new direct-acting antiviral therapies (DAAs), marking the beginning of a new era in HCV treatment. These treatments promise cure rates of over 90%, an improved safety profile, and a reduced duration of therapy compared to previous interferon-based regimens. This article aims to examine the evolution of HCV treatment, with a special focus on recent innovations in antiviral therapy. We will analyze the mechanisms of action of DAAs, their efficacy and safety, and their impact on populations with limited access to treatment. Additionally, we discuss the remaining challenges in the path to HCV eradication, including late diagnosis, barriers to treatment access, and the need for long-term monitoring of cured patients. By consolidating data from recent clinical studies and reviewing the specialized literature, this article provides a comprehensive perspective on the current landscape of HCV treatment, highlighting significant progress made and underlining the future directions needed to address remaining challenges. Finally, we reaffirm the importance of an integrated approach, encompassing prevention, early diagnosis, and universal access to innovative treatments, as a cornerstone in the fight against HCV.

Treatment Revolution: The New Era Against Hepatitis C

University of Medicine and Pharmacy “Grigore T. Popa”

Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Treatment Revolution: The New Era Against Hepatitis C"}

In recent decades, chronic viral infection C (HCV) has posed a major public health challenge globally, considering the morbidity and mortality associated with...

Treatment Revolution: The New Era Against Hepatitis C

Published Online: Jun 12, 2024

Page range: 79 - 84

DOI: https://doi.org/10.2478/inmed-2024-0290

Keywords
chronic viral infection C, new direct acting antiviral therapies, treatment revolution

© 2024 Oana Irina Gavril et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Treatment Revolution: The New Era Against Hepatitis C

Published Online: Jun 12, 2024

Page range: 79 - 84

DOI: https://doi.org/10.2478/inmed-2024-0290

Keywordschronic viral infection C, new direct acting antiviral therapies, treatment revolution

© 2024 Oana Irina Gavril et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
chronic viral infection C, new direct acting antiviral therapies, treatment revolution