<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Renal pathology is a pluralism of acute or chronic conditions in which the main victim is the nephron. Regardless of the nature of the injury, the primary lesion will always lead - in absence of efficient treatment - to end-stage kidney disease and renal replacement therapy. Although we are in the 21st century and amazing advances have been recorded in the medical field, the diagnosis of chronic kidney disease is performed - most frequently - based on the estimation of the glomerular filtration rate, based on serum creatinine. Unfortunately the serum creatinine level increases only when > 50% of the nephrons are already irremediably destroyed. In the last 20 years, an intensive research is performed in order to discover new plasma or urinary biomarkers for an earlier diagnosis of the renal pathology. Neutrophil gelatinase-associated lipocalin (NGAL) has a central place in this research, and its diagnostic and prognostic utility is proven particularly in acute kidney injury, but also in glomerulonephrites, diabetic nephropathy, and chronic kidney disease.</p></abstract>

Renal pathology is a pluralism of acute or chronic conditions in which the main victim is the nephron. Regardless of the nature of the injury, the primary lesion will always lead - in absence of efficient treatment - to end-stage kidney disease and renal replacement therapy. Although we are in the 21st century and amazing advances have been recorded in the medical field, the diagnosis of chronic kidney disease is performed - most frequently - based on the estimation of the glomerular filtration rate, based on serum creatinine. Unfortunately the serum creatinine level increases only when > 50% of the nephrons are already irremediably destroyed. In the last 20 years, an intensive research is performed in order to discover new plasma or urinary biomarkers for an earlier diagnosis of the renal pathology. Neutrophil gelatinase-associated lipocalin (NGAL) has a central place in this research, and its diagnostic and prognostic utility is proven particularly in acute kidney injury, but also in glomerulonephrites, diabetic nephropathy, and chronic kidney disease.

NGAL – Urinary Biomarker With Pathologic Significance in Nephrology Practice

Department of Nephrology, “Carol Davila”, Clinical Hospital of Nephrology

Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Renal pathology is a pluralism of acute or chronic conditions in which the main victim is the nephron. Regardless of the nature of the injury, the primary...

NGAL – Urinary Biomarker With Pathologic Significance in Nephrology Practice

Published Online: Jul 18, 2019

Page range: 7 - 18

DOI: https://doi.org/10.2478/inmed-2019-0056

Keywords
acute kidney injury, glomerulonephrites, diabetic nephropathy, chronic kidney disease, urinary biomarker, neutrophil gelatinase-associated lipocalin

© 2019 Mădălina-Gabriela Stăncescu, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

NGAL – Urinary Biomarker With Pathologic Significance in Nephrology Practice

Published Online: Jul 18, 2019

Page range: 7 - 18

DOI: https://doi.org/10.2478/inmed-2019-0056

Keywordsacute kidney injury, glomerulonephrites, diabetic nephropathy, chronic kidney disease, urinary biomarker, neutrophil gelatinase-associated lipocalin

© 2019 Mădălina-Gabriela Stăncescu, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
acute kidney injury, glomerulonephrites, diabetic nephropathy, chronic kidney disease, urinary biomarker, neutrophil gelatinase-associated lipocalin