Internal Medicine

<abstract><title style='display:none'>Abstract</title><bold>Introduction.</bold> The treatment of neoplasia has advanced due to targeted molecular therapies. Erlotinib, a tyrosine kinase inhibitor that acts by blocking epidermal growth factor receptor (EGFR), is used to treat advanced or metastatic chemotherapy-resistant non-small cell lung cancers (NSCLC).Erlotinib is a safe and well tolerated medication. Although the most common adverse effects are cutaneous or gastrointestinal, its cardiotoxicity is an important topic in the treatment and follow-up of neoplastic patients.<bold>Clinical case.</bold> A 76-year-old male patient with 40 Pack Year history of smoking that has quitted 20 years ago, was admitted in 2009 for night sweats, dry cough and weight loss. He is diagnosed with lung cancer in the right upper lobe (T4N2M1), with the histopathological diagnosis of clear cell adenocarcinoma. The patient performs radiotherapy and chemotherapy with 6 series of Gemcitabine and Cisplatin with partial response, followed by Erlotinib treatment with favorable progression with regression of tumor size.In December 2017, he presents recurrent episodes of atypical angina lasting about 2 weeks. The electrocardiographic examination reveals ST segment elevation, with tall T waves and Q waves are present in the lower branches, associated with the increase of myocardial necrosis enzymes. Echocardiography highlights inferior hypokinesia with left ventricle ejection rate estimated at 45%. The patient has a favorable evolution during admission without recurrence of pain. Coronary angiography is performed at distance with evidence of vascular atherosclerotic lesions and the installation of active pharmacodynamic stents.<bold>Discussions.</bold> Tyrosine kinase inhibitors may be the cause of acute coronary events both by affecting myocardiocytes following EGFR inhibition, but also by increasing atheromatic plaque instability and by prolonging theQT segment.In conclusion a systemic cardiologic assessment of Erlotinib-treated patients may be recommended throughout the course of therapy.</abstract>

Abstract

University of Medicine and Pharmacy Carol Davila Bucharest

Keywords

<article-title>Acute Coronary Syndrome Following Long-Term Erlotinib Treatment</article-title>

Acute Coronary Syndrome Following Long-Term Erlotinib Treatment

{"article-title":"Acute Coronary Syndrome Following Long-Term Erlotinib Treatment"}

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Editor-in-Chief Prof. Dr. I. Bruckner, UMF “Carol Davila”, Romania Managing Editor Conf. Dr. D. Isacoff, UMF “Carol Davila”, Romania Editorial Advisory Board Asist. univ. dr. Corina Homentcoschi, UMF “Carol Davila”, Romania Sef Lucrari Dr. Adriana Gurghean, UMF “Carol Davila”, Romania Asist. univ. dr. Ilinca Săvulescu-Fiedler, UMF “Carol Davila”, Romania Editors Prof. Dr. Eduard Apetrei (Bucureşti), Prof. Cătălina Arsenescu-Georgescu (Iaşi), Prof. Dr. Werner Bauer (Elveţia), Conf. Dr. Horia Bălan (Bucureşti), Prof. Dr. Miron Bogdan (Bucureşti), Dr. Gheorghe Cerin (Italia), Prof. Dr. Dan Cheţa (Bucureşti), Prof. Dr. Tudorel Ciurea (Craiova), Prof. Dr. Maria Dorobanţu (Bucureşti), Prof. Dr. Mircea Diculescu (Bucureşti), Prof. Dr. Dan L Dumitraşcu (Cluj), Prof. Dr. Andrei Gheorghe Dan (Bucureşti), Prof. Dr. J.W. Elte (Olanda), Prof. Dr. Carmen Fierbinţeanu Braticevici Technical Editors Dr. Roxana Pioaru Publisher De Gruyter Poland Bogumiła Zuga 32A Str. 01-811 Warsaw, Poland T: +48 22 701 50 15

Internal Medicine

Acute Coronary Syndrome Following Long-Term Erlotinib Treatment

Traian Constantin Panciu,
Traian Constantin Panciu,
Bianca Masgras,
Bianca Masgras,
Catrinel Ciuca,
Catrinel Ciuca,
Raluca Ciomag,
Raluca Ciomag,
Anca Mihăilescu and
Anca Mihăilescu and
Adriana Gurghean
Adriana Gurghean

Published Online: 20 Jul 2018

Volume & Issue: Volume 15 (2018) - Issue 3 (July 2018)

Page range: 61 - 66

Journal & Issue Details

Internal Medicine

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Internal Medicine

Acute Coronary Syndrome Following Long-Term Erlotinib Treatment

Traian Constantin Panciu,Traian Constantin Panciu,Bianca Masgras,Bianca Masgras,Catrinel Ciuca,Catrinel Ciuca,Raluca Ciomag,Raluca Ciomag,Anca Mihăilescu andAnca Mihăilescu andAdriana GurgheanAdriana Gurghean

Published Online: 20 Jul 2018

Volume & Issue: Volume 15 (2018) - Issue 3 (July 2018)

Page range: 61 - 66

Journal & Issue Details

Internal Medicine

PDF Preview

References

Recent Articles

Plan your remote conference with Sciendo

Traian Constantin Panciu,
Traian Constantin Panciu,
Bianca Masgras,
Bianca Masgras,
Catrinel Ciuca,
Catrinel Ciuca,
Raluca Ciomag,
Raluca Ciomag,
Anca Mihăilescu and
Anca Mihăilescu and
Adriana Gurghean
Adriana Gurghean