<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The objectives of this study were to evaluate transdermal scopolamine for motion sickness prophylaxis, and to evaluate off-vertical axis rotation (OVAR) as a laboratory model of motion sickness. This was a randomized, prospective, double-blind study design, set in a vestibular research laboratory. The experimental subjects consisted of 12 patients – 7 male, 5 female – ages 21 to 57, with normal auditory/vestibular function. The intervention was off-vertical axis rotation 20 degrees in the dark after administration of transdermal scopolamine or placebo. The main outcome measures were time duration of tolerated off-vertical rotation, and subjective symptom reporting during rotation at one-minute intervals on a 0–4 scale. Results were as follows: patients treated with transdermal scopolamine had statistically significant improved tolerance time to off-vertical axis rotation. Reported symptom-atology on the 0–4 subjective symptom scale was significantly improved, as compared to placebo, and was dose-dependent. Conclusions are as follows: off-vertical axis rotation is a useful modality for the evaluation of motion sickness medications. Transdermal scopolamine showed statistically significant dose-dependent effects in mitigating OVAR-induced motion sickness symptomatology and was well tolerated.</p></abstract>

The objectives of this study were to evaluate transdermal scopolamine for motion sickness prophylaxis, and to evaluate off-vertical axis rotation (OVAR) as a laboratory model of motion sickness. This was a randomized, prospective, double-blind study design, set in a vestibular research laboratory. The experimental subjects consisted of 12 patients – 7 male, 5 female – ages 21 to 57, with normal auditory/vestibular function. The intervention was off-vertical axis rotation 20 degrees in the dark after administration of transdermal scopolamine or placebo. The main outcome measures were time duration of tolerated off-vertical rotation, and subjective symptom reporting during rotation at one-minute intervals on a 0–4 scale. Results were as follows: patients treated with transdermal scopolamine had statistically significant improved tolerance time to off-vertical axis rotation. Reported symptom-atology on the 0–4 subjective symptom scale was significantly improved, as compared to placebo, and was dose-dependent. Conclusions are as follows: off-vertical axis rotation is a useful modality for the evaluation of motion sickness medications. Transdermal scopolamine showed statistically significant dose-dependent effects in mitigating OVAR-induced motion sickness symptomatology and was well tolerated.

Off-Vertical Axis Rotational Assessment of Transdermal Scopolamine for Motion Sickness Prophylaxis

Bionetics Corporation, NASA-Kennedy Space Center

University of Florida College of Medicine, UF Health–Jacksonville

Department of Neurotology Research, Legacy Health System

Gravitational and Space Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The objectives of this study were to evaluate transdermal scopolamine for motion sickness prophylaxis, and to evaluate off-vertical axis rotation (OVAR) as a...

Off-Vertical Axis Rotational Assessment of Transdermal Scopolamine for Motion Sickness Prophylaxis

Article Category: Research Article

Published Online: Mar 02, 2022

Page range: 13 - 20

DOI: https://doi.org/10.2478/gsr-2014-0014

Keywords
Off-Vertical, Vestibular, Motion Sickness, Scopolamine, Rotational, Off-Vertical Rotation, OVAR

© 2014 Daniel Woodard et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Off-Vertical Axis Rotational Assessment of Transdermal Scopolamine for Motion Sickness Prophylaxis

Article Category: Research Article

Published Online: Mar 02, 2022

Page range: 13 - 20

DOI: https://doi.org/10.2478/gsr-2014-0014

KeywordsOff-Vertical, Vestibular, Motion Sickness, Scopolamine, Rotational, Off-Vertical Rotation, OVAR

© 2014 Daniel Woodard et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Off-Vertical, Vestibular, Motion Sickness, Scopolamine, Rotational, Off-Vertical Rotation, OVAR