<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The main pathological change in post-traumatic osteoarthritis (PTOA) is cartilage degeneration, which is closely related to inflammation and oxidative stress. Inflammation can cause degeneration of articular cartilage. Cartilage degeneration can also stimulate the progression of inflammation. It has been found that inflammatory cytokines can participate in the pathological process of cartilage degeneration through multiple signaling pathways, mainly mitogen-activated protein kinase, nuclear transcription factor kappa B, and Wnt–β-catenin signal transduction pathways. This review aimed at exploring the relationship between PTOA and inflammation-related cytokines by introducing the role of proinflammatory cytokines in chondrocyte destruction and extracellular matrix degradation.</p></abstract>

The main pathological change in post-traumatic osteoarthritis (PTOA) is cartilage degeneration, which is closely related to inflammation and oxidative stress. Inflammation can cause degeneration of articular cartilage. Cartilage degeneration can also stimulate the progression of inflammation. It has been found that inflammatory cytokines can participate in the pathological process of cartilage degeneration through multiple signaling pathways, mainly mitogen-activated protein kinase, nuclear transcription factor kappa B, and Wnt–β-catenin signal transduction pathways. This review aimed at exploring the relationship between PTOA and inflammation-related cytokines by introducing the role of proinflammatory cytokines in chondrocyte destruction and extracellular matrix degradation.

Initial effects of inflammation-related cytokines and signaling pathways on the pathogenesis of post-traumatic osteoarthritis

Frontiers of Nursing

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The main pathological change in post-traumatic osteoarthritis (PTOA) is cartilage degeneration, which is closely related to inflammation and oxidative stress....

Initial effects of inflammation-related cytokines and signaling pathways on the pathogenesis of post-traumatic osteoarthritis

Article Category: Review Article

Published Online: Aug 14, 2018

Page range: 91 - 96

Received: Jan 02, 2018

Accepted: Jan 30, 2018

DOI: https://doi.org/10.2478/fon-2018-0012

Keywords
post-traumatic osteoarthritis, cartilage degeneration, proinflammatory cytokine, signaling pathway

© 2018 Peng-Fei Han, Zhi-Liang Zhang, Tao-Yu Chen, Rui-Peng Zhao, Rong Zhang, Xiao-Dong Li, Peng-Cui Li, Lei Wei, Zhi Lv, Xiao-Chun Wei, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Initial effects of inflammation-related cytokines and signaling pathways on the pathogenesis of post-traumatic osteoarthritis

Article Category: Review Article

Published Online: Aug 14, 2018

Page range: 91 - 96

Received: Jan 02, 2018

Accepted: Jan 30, 2018

DOI: https://doi.org/10.2478/fon-2018-0012

Keywordspost-traumatic osteoarthritis, cartilage degeneration, proinflammatory cytokine, signaling pathway

© 2018 Peng-Fei Han, Zhi-Liang Zhang, Tao-Yu Chen, Rui-Peng Zhao, Rong Zhang, Xiao-Dong Li, Peng-Cui Li, Lei Wei, Zhi Lv, Xiao-Chun Wei, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Keywords
post-traumatic osteoarthritis, cartilage degeneration, proinflammatory cytokine, signaling pathway