<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) are widely used to assess patient’s outcome in many types of neoplasms including breast cancer. The aim of this study was to select the best parameter with a high prognostic value by defining the optimal cutoff value for each parameter in patients undergoing mastectomy.</p>
</sec>
<sec><h3>Patients and Methods</h3>
<p>This is a retrospective monocentric study enrolling 59 patients. The receiver operating characteristic (ROC) curve was used for the obtention of the optimal cutoff values of NLR, PLR, MLR, SII, and SIRI. The Kaplan–Meier curve and log-rank test were used to assess recurrence-free survival (RFS), distant metastasis-free survival (DMFS), and overall survival (OS).</p>
</sec>
<sec><h3>Results</h3>
<p>Among the five parameters, we obtained the optimal cutoff values for NLR, MLR, SII, and NLR but not for PLR (AUC ≤0.5). To assess the RFS, the optimal cutoff values for NLR, MLR, SII, and SIRI were defined as 2.11, 0.16, 472, and 0.6888, respectively. High MLR (p= 0.0165), SII (p= 0.0368), and SIRI (p= 0.012) were associated to shorter RFS. For DMFS, the optimal cutoff values for NLR, MLR, SII, and SIRI were 1.60, 0.28, 472, and 0.6888, respectively. Interestingly, the Kaplan–Meier curve showed that patients with high MLR (p&lt; 0.0001), SII (p= 0.0345), and SIRI (p= 0.0255) exhibited shorter DMFS.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>The MLR, SII, and SIRI indices would be the best indicators. They could constitute a promising predictive tool in the detection of locoregional and distant metastasis.</p>
</sec>
</abstract>

Background
Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) are widely used to assess patient’s outcome in many types of neoplasms including breast cancer. The aim of this study was to select the best parameter with a high prognostic value by defining the optimal cutoff value for each parameter in patients undergoing mastectomy.

Patients and Methods
This is a retrospective monocentric study enrolling 59 patients. The receiver operating characteristic (ROC) curve was used for the obtention of the optimal cutoff values of NLR, PLR, MLR, SII, and SIRI. The Kaplan–Meier curve and log-rank test were used to assess recurrence-free survival (RFS), distant metastasis-free survival (DMFS), and overall survival (OS).

Results
Among the five parameters, we obtained the optimal cutoff values for NLR, MLR, SII, and NLR but not for PLR (AUC ≤0.5). To assess the RFS, the optimal cutoff values for NLR, MLR, SII, and SIRI were defined as 2.11, 0.16, 472, and 0.6888, respectively. High MLR (p= 0.0165), SII (p= 0.0368), and SIRI (p= 0.012) were associated to shorter RFS. For DMFS, the optimal cutoff values for NLR, MLR, SII, and SIRI were 1.60, 0.28, 472, and 0.6888, respectively. Interestingly, the Kaplan–Meier curve showed that patients with high MLR (p< 0.0001), SII (p= 0.0345), and SIRI (p= 0.0255) exhibited shorter DMFS.

Conclusions
The MLR, SII, and SIRI indices would be the best indicators. They could constitute a promising predictive tool in the detection of locoregional and distant metastasis.

Prognostic value of pro-inflammatory markers at the preoperative stage in Algerian women with breast cancer

Laboratory of Cellular and Molecular Biology (LBCM), Team Cytokines and Nitric Oxide Synthase

Immunity and Pathogeny, Faculty of Biological Sciences

University of Sciences and Technology Houari Boumediene (USTHB)

Laboratory of oxidative stress, kidney and associated complications, Team Cancer and oxidative stress

Faculty of Medicine, University of Algiers 1

Department of Biology, Faculty of Sciences

Forum of Clinical Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Background
Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index...

Prognostic value of pro-inflammatory markers at the preoperative stage in Algerian women with breast cancer

Article Category: Research Article

Published Online: Jun 18, 2024

Page range: -

Received: Oct 28, 2023

Accepted: Jan 22, 2024

DOI: https://doi.org/10.2478/fco-2023-0021

Keywords
breast cancer, SII, MLR, SIRI, prognostic factor, survival

© 2023 Ahmed Amine Zergoun et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Prognostic value of pro-inflammatory markers at the preoperative stage in Algerian women with breast cancer

Article Category: Research Article

Published Online: Jun 18, 2024

Page range: -

Received: Oct 28, 2023

Accepted: Jan 22, 2024

DOI: https://doi.org/10.2478/fco-2023-0021

Keywordsbreast cancer, SII, MLR, SIRI, prognostic factor, survival

© 2023 Ahmed Amine Zergoun et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
breast cancer, SII, MLR, SIRI, prognostic factor, survival