<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>The presence of lymph node metastasis is one of the most important prognostic factors for long-term survival of patients with colorectal cancer. Therefore, thorough pathologic examination of at least 12 lymph nodes is essential for accurate staging of this disease, as well as for choosing the best adjuvant treatment. The aim of this study is to assess the adequacy of lymph node harvest in patients with colorectal cancer.</p>
</sec>
<sec><h3>Methods</h3>
<p>This observational, cross-sectional study was performed on 584 patients with colorectal adenocarcinoma who had undergone surgery from 2012 to 2017. Thereafter, the relevant demographic, pathological, and surgical data were extracted from the patients’ medical records; and a relationship between the number of evaluated lymph nodes and other variables was also assessed.</p>
</sec>
<sec><h3>Results</h3>
<p>Among 584 studies cases in this study, 336 (57.5%) subjects had fewer than 12 evaluated lymph nodes. Mean and median number of the evaluated lymph nodes were calculated as 10.7 (±5.6) and 10, respectively. The patients aged 60 years old and older and the cases with tumors located in descending colon and rectum were observed to have a higher likelihood of inadequate lymph node retrieval. After an average follow-up of a 60-month period, 63% of the patients were alive. For the patients in whom fewer than 12 lymph nodes had been assessed, the median survival was estimated to be 48 months. For the patients in whom the number of evaluated lymph nodes was ≥12, median survival was calculated to be 54 months.</p>
</sec>
<sec><h3>Conclusion</h3>
<p>The number of lymph nodes evaluated in our study was less than the standard number in more than half of the patients. Among various other factors, older age and tumor location in descending colon and rectum are found to be associated with suboptimal assessment of lymph nodes. The number of lymph nodes dissected is also associated with survival.</p>
</sec>
</abstract>

Background
The presence of lymph node metastasis is one of the most important prognostic factors for long-term survival of patients with colorectal cancer. Therefore, thorough pathologic examination of at least 12 lymph nodes is essential for accurate staging of this disease, as well as for choosing the best adjuvant treatment. The aim of this study is to assess the adequacy of lymph node harvest in patients with colorectal cancer.

Methods
This observational, cross-sectional study was performed on 584 patients with colorectal adenocarcinoma who had undergone surgery from 2012 to 2017. Thereafter, the relevant demographic, pathological, and surgical data were extracted from the patients’ medical records; and a relationship between the number of evaluated lymph nodes and other variables was also assessed.

Results
Among 584 studies cases in this study, 336 (57.5%) subjects had fewer than 12 evaluated lymph nodes. Mean and median number of the evaluated lymph nodes were calculated as 10.7 (±5.6) and 10, respectively. The patients aged 60 years old and older and the cases with tumors located in descending colon and rectum were observed to have a higher likelihood of inadequate lymph node retrieval. After an average follow-up of a 60-month period, 63% of the patients were alive. For the patients in whom fewer than 12 lymph nodes had been assessed, the median survival was estimated to be 48 months. For the patients in whom the number of evaluated lymph nodes was ≥12, median survival was calculated to be 54 months.

Conclusion
The number of lymph nodes evaluated in our study was less than the standard number in more than half of the patients. Among various other factors, older age and tumor location in descending colon and rectum are found to be associated with suboptimal assessment of lymph nodes. The number of lymph nodes dissected is also associated with survival.

Evaluation of lymph node adequacy in patients with colorectal cancer: Results from a referral center in Iran

Shahid Beheshti University of Medical Sciences

Biostatistics Tehran University of Medical Sciences

Forum of Clinical Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Background
The presence of lymph node metastasis is one of the most important prognostic factors for long-term survival of patients with colorectal cancer....

Evaluation of lymph node adequacy in patients with colorectal cancer: Results from a referral center in Iran

Article Category: Research Article

Published Online: Aug 03, 2023

Page range: 9 - 14

Received: Nov 02, 2021

Accepted: Apr 13, 2022

DOI: https://doi.org/10.2478/fco-2022-0013

Keywords
colorectal cancer, lymph node, lymphadenectomy, malignancies, survival

© 2022 Hossein Yahyazadeh et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Evaluation of lymph node adequacy in patients with colorectal cancer: Results from a referral center in Iran

Article Category: Research Article

Published Online: Aug 03, 2023

Page range: 9 - 14

Received: Nov 02, 2021

Accepted: Apr 13, 2022

DOI: https://doi.org/10.2478/fco-2022-0013

Keywordscolorectal cancer, lymph node, lymphadenectomy, malignancies, survival

© 2022 Hossein Yahyazadeh et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
colorectal cancer, lymph node, lymphadenectomy, malignancies, survival