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Journals
Forum of Clinical Oncology
Volume 13 (2022): Issue 1 (December 2022)
Open Access
Retroperitoneal pararenal dedifferentiated liposarcoma with epithelioid/neuroendocrine features, somatostatin-positive.
Gabriele Gaggero
Gabriele Gaggero
,
Paola Bet
Paola Bet
,
Davide Taietti
Davide Taietti
,
Marta Ingaliso
Marta Ingaliso
and
Bruno Spina
Bruno Spina
| Aug 03, 2023
Forum of Clinical Oncology
Volume 13 (2022): Issue 1 (December 2022)
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Article Category:
Research Article
Published Online:
Aug 03, 2023
Page range:
63 - 65
Received:
Nov 13, 2022
Accepted:
Jan 04, 2023
DOI:
https://doi.org/10.2478/fco-2022-0007
Keywords
liposarcoma
,
dedifferentiated
,
epithelioid
,
neuroendocrine
,
somatostatin
,
MDM2
© 2022 Gabriele Gaggero et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1:
Photomicrographs of liposarcoma with epithelioid/neuroendocrine dedifferentiation: A) histological view of a neoplasm organised in nests separated by thin fibrovascular branches, cytologically of epithelioid appearance (Hematoxilin and Eosin, 20×); B) at higher magnification, spindle/elongated neoplastic elements, also with mitosis (arrow), are observed at the edges of the epithelioid neoplasm, suggesting a possible mesenchymal origin (Hematoxilin and Eosin, 40×); C) immunohistochemistry for NSE, showing positivity in scattered neoplastic cells (10×); D) immunohistochemistry for somatostatin, showing ‹dot like› positivity in epithelioid neoplastic cells (10×).
Figure 2:
FISH photomicrograph showing a liposarcoma tissue section with amplification of the MDM2 gene (green signal), compared to the control CEN 12 (orange signal).