<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy in Asia. Most patients in Cipto Mangunkusumo Hospital have been diagnosed with an advanced stage. There had not been any survival study for OSCC in Indonesia. This study aimed to investigate the survival rate and prognostic factors of OSCC in Cipto Mangunkusumo Hospital.</p>
</sec>
<sec><h3>Methods</h3>
<p>A retrospective cohort study was conducted on OSCC patients diagnosed and treated in Cipto Mangunkusumo Hospital from 2014 to 2018. Data regarding age, gender, site of the primary lesion, clinical stage of the disease, tumor differentiation, invasion, and surgical margins were collected. The main outcomes measured were overall survival (OS) and disease-specific survival (DSS). The predictors of survival were then determined.</p>
</sec>
<sec><h3>Result</h3>
<p>169 patients were included. The majority of patients were male (51.5%) and above 50 years old (55.6%). The most prevalent tumor site was the tongue (72.8%) followed by buccal mucosa (13%). The majority (82.2%) of patients had advanced (clinical stage IV) disease at diagnosis. A smaller majority of patients had a well-differentiated tumor (60.4%) and a low-grade tumor (53.8%). The worst one-year and two-year overall survival rates were found in the stage IV group (53.5% and 37.5%, respectively). The disease-specific survival rate was 66.9%.</p>
</sec>
<sec><h3>Conclusion</h3>
<p>The one-year and two-year overall survival rates of OSCC in Cipto Mangunkusumo Hospital were 58.6% and 43.1%. Moreover, clinical stage, tumor size, and lymph node involvement were the most significant prognostic factors for OSCC.</p>
</sec>
</abstract>

Background
Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy in Asia. Most patients in Cipto Mangunkusumo Hospital have been diagnosed with an advanced stage. There had not been any survival study for OSCC in Indonesia. This study aimed to investigate the survival rate and prognostic factors of OSCC in Cipto Mangunkusumo Hospital.

Methods
A retrospective cohort study was conducted on OSCC patients diagnosed and treated in Cipto Mangunkusumo Hospital from 2014 to 2018. Data regarding age, gender, site of the primary lesion, clinical stage of the disease, tumor differentiation, invasion, and surgical margins were collected. The main outcomes measured were overall survival (OS) and disease-specific survival (DSS). The predictors of survival were then determined.

Result
169 patients were included. The majority of patients were male (51.5%) and above 50 years old (55.6%). The most prevalent tumor site was the tongue (72.8%) followed by buccal mucosa (13%). The majority (82.2%) of patients had advanced (clinical stage IV) disease at diagnosis. A smaller majority of patients had a well-differentiated tumor (60.4%) and a low-grade tumor (53.8%). The worst one-year and two-year overall survival rates were found in the stage IV group (53.5% and 37.5%, respectively). The disease-specific survival rate was 66.9%.

Conclusion
The one-year and two-year overall survival rates of OSCC in Cipto Mangunkusumo Hospital were 58.6% and 43.1%. Moreover, clinical stage, tumor size, and lymph node involvement were the most significant prognostic factors for OSCC.

Survival rate and prognostic factors of oral squamous cell carcinoma in Indonesia: A single-center retrospective study

Surgical Oncology Division, Department of Surgery, Faculty of Medicine

Department of Surgery, Faculty of Medicine

Department of Anatomic Pathology, Faculty of Medicine

Department of Community Medicine, Faculty of Medicine

Forum of Clinical Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Background
Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy in Asia. Most patients in Cipto Mangunkusumo Hospital have been diagnosed...

Survival rate and prognostic factors of oral squamous cell carcinoma in Indonesia: A single-center retrospective study

Article Category: Research Article

Published Online: Jul 13, 2022

Page range: 15 - 22

Received: Nov 14, 2021

Accepted: Apr 13, 2022

DOI: https://doi.org/10.2478/fco-2021-0013

Keywords
oral cancer, squamous cell carcinoma, prognosis, survival, Indonesia

© 2022 Diani Kartini et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Survival rate and prognostic factors of oral squamous cell carcinoma in Indonesia: A single-center retrospective study

Article Category: Research Article

Published Online: Jul 13, 2022

Page range: 15 - 22

Received: Nov 14, 2021

Accepted: Apr 13, 2022

DOI: https://doi.org/10.2478/fco-2021-0013

Keywordsoral cancer, squamous cell carcinoma, prognosis, survival, Indonesia

© 2022 Diani Kartini et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
oral cancer, squamous cell carcinoma, prognosis, survival, Indonesia