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<sec><h3>Background</h3><p>Breast cancer (BC) is the principal cause of cancer related deaths among women worldwide. The available evidence suggests that cardio-metabolic risk factors such as dyslipidemia and hypertension may contribute differently to breast cancer severity and pathogenesis. The aim of this study is to evaluate the interactive role of BC on dyslipidemia and HTN risk according to the type of treatment exposure and menopausal status.</p></sec>
<sec><h3>Patients and methods</h3><p>Observational experimental design implemented; permit to include 134 newly-diagnosed patients who were naïve to any type of treatment interventions and 262 recently-diagnosed patients during their first three months of treatments’ exposure including chemotherapy treatments. Patients with breast cancer were evaluated for dyslipidemia and hypertension biomarkers.</p></sec>
<sec><h3>Results</h3><p>About 5.0% of breast cancer patients had dyslipidemia. The prevalence of increased triglycerides and total cholesterol were more frequent (<italic>p</italic> &lt; 0.05) in recently-diagnosed group than in newly-diagnosed patients. While 23% of patients had overt hypertension, with higher (<italic>p</italic> &lt; 0.05) prevalence in chemo group (28%), triglycerides was higher (<italic>p</italic> &lt; 0.05) in postmenopausal than premenopausal BC patients (221.0 ± 5.9 vs. 195 ± 4.7 mg/dl). Similarly, the prevalence of abnormal systolic blood pressure (9% vs. 5%) and diastolic blood pressure (11% vs. 7%) was higher (<italic>p</italic> &lt; 0.05) in postmenopausal patients.</p></sec>
<sec><h3>Conclusions</h3><p>Dyslipidemia and hypertension biomarkers were prevalent among breast cancer patients and the risk increased in postmenopausal women and after treatments’ exposure specially chemotherapy. This conclusion requires a closer attention by healthcare professionals in order to improve the outcomes after diagnosis and to enhance treatment exposure regarding postmenopausal women.</p></sec>
</abstract>

BackgroundBreast cancer (BC) is the principal cause of cancer related deaths among women worldwide. The available evidence suggests that cardio-metabolic risk factors such as dyslipidemia and hypertension may contribute differently to breast cancer severity and pathogenesis. The aim of this study is to evaluate the interactive role of BC on dyslipidemia and HTN risk according to the type of treatment exposure and menopausal status.
Patients and methodsObservational experimental design implemented; permit to include 134 newly-diagnosed patients who were naïve to any type of treatment interventions and 262 recently-diagnosed patients during their first three months of treatments’ exposure including chemotherapy treatments. Patients with breast cancer were evaluated for dyslipidemia and hypertension biomarkers.
ResultsAbout 5.0% of breast cancer patients had dyslipidemia. The prevalence of increased triglycerides and total cholesterol were more frequent (p < 0.05) in recently-diagnosed group than in newly-diagnosed patients. While 23% of patients had overt hypertension, with higher (p < 0.05) prevalence in chemo group (28%), triglycerides was higher (p < 0.05) in postmenopausal than premenopausal BC patients (221.0 ± 5.9 vs. 195 ± 4.7 mg/dl). Similarly, the prevalence of abnormal systolic blood pressure (9% vs. 5%) and diastolic blood pressure (11% vs. 7%) was higher (p < 0.05) in postmenopausal patients.
ConclusionsDyslipidemia and hypertension biomarkers were prevalent among breast cancer patients and the risk increased in postmenopausal women and after treatments’ exposure specially chemotherapy. This conclusion requires a closer attention by healthcare professionals in order to improve the outcomes after diagnosis and to enhance treatment exposure regarding postmenopausal women.

Interactive role of breast cancer on dyslipidemia and hypertension metabolic risk according to treatment exposure and menopausal status

Al-Zarqa University College, Al-Balqa Applied University

Department of Nutrition and Food Technology, Faculty of Agriculture

Breast Cancer Unite, Department of General Surgery, King Hussein Medical Center

Forum of Clinical Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

BackgroundBreast cancer (BC) is the principal cause of cancer related deaths among women worldwide. The available evidence suggests that cardio-metabolic risk...

Interactive role of breast cancer on dyslipidemia and hypertension metabolic risk according to treatment exposure and menopausal status

Article Category: Research Article

Published Online: May 02, 2021

Page range: 39 - 46

Received: Jun 30, 2018

Accepted: Apr 29, 2019

DOI: https://doi.org/10.2478/fco-2019-0018

Keywords
Breast cancer, chemotherapy, hypertension, lipid profile

© 2021 Safaa A. Al-Zeidaneen et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Interactive role of breast cancer on dyslipidemia and hypertension metabolic risk according to treatment exposure and menopausal status

Article Category: Research Article

Published Online: May 02, 2021

Page range: 39 - 46

Received: Jun 30, 2018

Accepted: Apr 29, 2019

DOI: https://doi.org/10.2478/fco-2019-0018

KeywordsBreast cancer, chemotherapy, hypertension, lipid profile

© 2021 Safaa A. Al-Zeidaneen et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Breast cancer, chemotherapy, hypertension, lipid profile