<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Objective.</bold> Adipose tissue is considered to be an endocrine organ that secretes bioactive substances known as adipokines that contribute to the pathophysiology of metabolic and coronary diseases related to obesity. In this study, various novel biomarkers, such as inflammatory markers that are pro-inflammatory (visfatin) and anti-inflammatory (omentin-1), as prognostic indicators for people with coronary artery disease (CAD) were investigated.
<bold>Methods.</bold> In this study, 30 diabetic patients with CAD, 30 diabetic patients without CAD, and 30 healthy control counterparts were included. Serum omentin and visfatin concentrations were evaluated by solid-phase enzyme linked immunosorbent assay (ELISA) kit. Patients with established diagnosis of CAD based on angiography, ECG, and elevated cardiac marker level were included into the study. Patients with cardioembolic stroke, cerebral venous sinus thrombosis, CNS vasculitis, and hemorrhage due to trauma, tumor, vascular malformation, and coagulopathy were excluded.
<bold>Results.</bold> The serum omentin-1 levels were significantly higher in the healthy controls in comparison with the diabetic group (p&lt;0.0001) and serum visfatin levels were significantly higher in the diabetic group in comparison with the healthy controls (p&lt;0.0001). The serum omentin levels were significantly higher in the diabetic group in comparison with the cardio-diabetic group (p&lt;0.0001) and serum visfatin levels were significantly higher in the cardio-diabetic group in comparison with the diabetic group (p&lt;0.0001). The serum omentin-1 showed negative correlation with the serum visfatin in the cardio-diabetic group.
<bold>Conclusion.</bold> The adipokines, such as omentin and visfatin, may be good therapeutic candidates in preventing or ameliorating CAD.
</abstract>

Objective. Adipose tissue is considered to be an endocrine organ that secretes bioactive substances known as adipokines that contribute to the pathophysiology of metabolic and coronary diseases related to obesity. In this study, various novel biomarkers, such as inflammatory markers that are pro-inflammatory (visfatin) and anti-inflammatory (omentin-1), as prognostic indicators for people with coronary artery disease (CAD) were investigated.
Methods. In this study, 30 diabetic patients with CAD, 30 diabetic patients without CAD, and 30 healthy control counterparts were included. Serum omentin and visfatin concentrations were evaluated by solid-phase enzyme linked immunosorbent assay (ELISA) kit. Patients with established diagnosis of CAD based on angiography, ECG, and elevated cardiac marker level were included into the study. Patients with cardioembolic stroke, cerebral venous sinus thrombosis, CNS vasculitis, and hemorrhage due to trauma, tumor, vascular malformation, and coagulopathy were excluded.
Results. The serum omentin-1 levels were significantly higher in the healthy controls in comparison with the diabetic group (p<0.0001) and serum visfatin levels were significantly higher in the diabetic group in comparison with the healthy controls (p<0.0001). The serum omentin levels were significantly higher in the diabetic group in comparison with the cardio-diabetic group (p<0.0001) and serum visfatin levels were significantly higher in the cardio-diabetic group in comparison with the diabetic group (p<0.0001). The serum omentin-1 showed negative correlation with the serum visfatin in the cardio-diabetic group.
Conclusion. The adipokines, such as omentin and visfatin, may be good therapeutic candidates in preventing or ameliorating CAD.

Evaluation of serum adipokines (omentin-1 and visfatin) in coronary artery disease at a North Indian hospital

Integral Institute of Medical Science and Research, Integral University

Department of Medicine, Integral Institute of Medical Science and Research

Department of Biochemistry, Faculty of Dentistry

Department of Basic Medical Sciences, Integral Institute of Allied Health Sciences and Research

Endocrine Regulations

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Objective. Adipose tissue is considered to be an endocrine organ that secretes bioactive substances known as adipokines that contribute to the pathophysiology...

Evaluation of serum adipokines (omentin-1 and visfatin) in coronary artery disease at a North Indian hospital

Published Online: Dec 21, 2023

Page range: 262 - 268

DOI: https://doi.org/10.2478/enr-2023-0029

Keywords
diabetes mellitus, coronary artery disease, omentin-1, visfatin, adipokines

© 2023 Saif Ali et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Evaluation of serum adipokines (omentin-1 and visfatin) in coronary artery disease at a North Indian hospital

Published Online: Dec 21, 2023

Page range: 262 - 268

DOI: https://doi.org/10.2478/enr-2023-0029

Keywordsdiabetes mellitus, coronary artery disease, omentin-1, visfatin, adipokines

© 2023 Saif Ali et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
diabetes mellitus, coronary artery disease, omentin-1, visfatin, adipokines