1. bookVolume 54 (2020): Issue 3 (July 2020)
Journal Details
License
Format
Journal
eISSN
1336-0329
First Published
30 Mar 2016
Publication timeframe
4 times per year
Languages
English
access type Open Access

Endocrine approach in the treatment of obesity: Is there any space for the adiponectin action?

Published Online: 27 Aug 2020
Volume & Issue: Volume 54 (2020) - Issue 3 (July 2020)
Page range: 157 - 159
Journal Details
License
Format
Journal
eISSN
1336-0329
First Published
30 Mar 2016
Publication timeframe
4 times per year
Languages
English
Abstract

Adiponectin is a hormone secreted by adipose tissue, exerting many positive effects in the human body. Its action has been widely studied, placing it into the metabolic health beneficial products of the adipose tissue. Nevertheless, adiponectin has been shown to exert some extra beneficial non metabolic actions, as well. Adiponectin levels can be related to reduced incidence of cancer in obese patients. Moreover, adiponectin has been shown to be implicated in the positive fertility outcomes of women. Some new studies have also indicated that adiponectin has a potential effect in the control of appetite, which raises a question, whether adiponectin could be accredited to be useful in the endocrine evaluation of obesity. Could these additional non-metabolic actions prove its helpfulness?

Keywords

Dalamaga M, Diakopoulos KN, Mantzoros CS. The role of adiponectin in cancer: a review of current evidence. Endocr Rev 33, 547–594, 2012.10.1210/er.2011-1015Search in Google Scholar

Kubota N, Yano W, Kubota T, Yamauchi T, Itoh S, Kumagai H, Kozono H, Takamoto I, Okamoto S, Shiuchi T, Suzuki R, Satoh H, Tsuchida A, Moroi M, Sugi K, Noda T, Ebinuma H, Ueta Y, Kondo T, Araki E, Ezaki O, Nagai R, Tobe K, Terauchi Y, Ueki K, Minokoshi Y, Kadowaki T. Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab 6, 55–68, 2007.10.1016/j.cmet.2007.06.003Search in Google Scholar

Michalakis K, Williams CJ, Mitsiades N, Blakeman J, Balafouta-Tselenis S, Giannopoulos A, Mantzoros CS. Serum adiponectin concentrations and tissue expression of adiponectin receptors are reduced in patients with prostate cancer: a case control study. Cancer Epidemiol Biomarkers Prev 16, 308–313, 2007.10.1158/1055-9965.EPI-06-0621Search in Google Scholar

Michalakis KG, Segars JH. The role of adiponectin in reproduction: from polycystic ovary syndrome to assisted reproduction. Fertil Steril 94, 1949–1957, 2010.10.1016/j.fertnstert.2010.05.010Search in Google Scholar

Michalakis K. Adiponectin: The “unusual suspect” between insulin resistance and cancer? Prostate Cancer Prostatic Dis 22, 636–637, 2019.10.1038/s41391-019-0142-5Search in Google Scholar

Nicolas S, Debayle D, Bechade C, Maroteaux L, Gay AS, Bayer P, Heurteaux C, Guyon A, Chabry J. Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression. Transl Psychiatry 8, 159, 2018.10.1038/s41398-018-0210-ySearch in Google Scholar

Pasquali R, Casanueva F, Haluzik M, van Hulsteijn L, Ledoux S, Monteiro MP, Salvador J, Santini F, Toplak H, Dekkers OM. European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity. Eur J Endocrinol 182, G1–G32, 2020.10.1530/EJE-19-0893Search in Google Scholar

Rifas-Shiman SL, Fleisch A, Hivert MF, Mantzoros C, Gillman MW, Oken E. First and second trimester gestational weight gains are most strongly associated with cord blood levels of hormones at delivery important for glycemic control and somatic growth. Metabolism 69, 112–119, 2017.10.1016/j.metabol.2017.01.019Search in Google Scholar

Qi Y, Takahashi N, Hileman SM, Patel HR, Berg AH, Pajvani UB, Scherer PE, Ahima RS. Adiponectin acts in the brain to decrease body weight. Nat Med 10, 524–529, 2004.10.1038/nm1029Search in Google Scholar

Seetho IW, Wilding JP. How to approach endocrine assessment in severe obesity? Clin Endocrinol (Oxf) 79, 163–167, 2013.10.1111/cen.12256Search in Google Scholar

Wang ZV, Scherer PE. Adiponectin, the past two decades. J Mol Cell Biol 8, 93–100, 2016.10.1093/jmcb/mjw011Search in Google Scholar

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