<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Objective</bold>: Allergic asthma is the most frequently observed subtype of individuals with asthma. The effects of serotonin plays in the pathophysiology of asthma has not been clearly determined. Thus, this study aimed to investigate the association between the <italic>5HTR2C</italic> gene rs 6318 G>C polymorphism and allergic asthma in pediatric patients in Cyprus.
<bold>Methods</bold>: This study included total number of 177 individuals with 118 control and 59 pediatric patients (43 atopic and 16 non-atopic asthma patient). A skin prick test was performed for each patient to confirm asthma diagnosis and to evaluate atopic status. Genotyping for the 5HTR2C was completed by Real Time-PCR analysis.
<bold>Results</bold>: The genotype distribution frequencies were not in agreement with the Hardy-Weinberg Equilibrium in the patients’ group (p&lt;0.00001). The frequency of the risk allele (allele C) was not significantly different between the patient and control groups (p=0.255). The genotypic distribution between atopic asthma and non-atopic asthma within the patientsts groups was not in agreement with the Hardy-Weinberg Equilibrium (p=0.006). However, risk allele presence showed a statistically significant association with atopy-related asthma (p=0.037).
<bold>Discussion &amp; Conclusion</bold>: Overall, despite the finding of no association between the 5HTR2C rs6318 C allele and childhood asthma, the current results indicated that there is a strong association between the 5HTR2C rs6318 C variant and childhood atopic asthma.
</abstract>

Objective: Allergic asthma is the most frequently observed subtype of individuals with asthma. The effects of serotonin plays in the pathophysiology of asthma has not been clearly determined. Thus, this study aimed to investigate the association between the 5HTR2C gene rs 6318 G>C polymorphism and allergic asthma in pediatric patients in Cyprus.
Methods: This study included total number of 177 individuals with 118 control and 59 pediatric patients (43 atopic and 16 non-atopic asthma patient). A skin prick test was performed for each patient to confirm asthma diagnosis and to evaluate atopic status. Genotyping for the 5HTR2C was completed by Real Time-PCR analysis.
Results: The genotype distribution frequencies were not in agreement with the Hardy-Weinberg Equilibrium in the patients’ group (p<0.00001). The frequency of the risk allele (allele C) was not significantly different between the patient and control groups (p=0.255). The genotypic distribution between atopic asthma and non-atopic asthma within the patientsts groups was not in agreement with the Hardy-Weinberg Equilibrium (p=0.006). However, risk allele presence showed a statistically significant association with atopy-related asthma (p=0.037).
Discussion & Conclusion: Overall, despite the finding of no association between the 5HTR2C rs6318 C allele and childhood asthma, the current results indicated that there is a strong association between the 5HTR2C rs6318 C variant and childhood atopic asthma.

Association of the <italic>5HTR2C</italic> gene Ser23 variation with childhood allergic asthma

Department of Medical Genetics, Faculty of Medicine

Department of Histology and Embryology, Faculty of Medicine

Department of Immunology, Faculty of Medicine

Department of Medical Biology, Faculty of Medicine

Department of Pediatrics, Faculty of Medicine

The EuroBiotech Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Association of the  gene Ser23 variation with childhood allergic asthma

Objective: Allergic asthma is the most frequently observed subtype of individuals with asthma. The effects of serotonin plays in the pathophysiology of asthma...

Association of the 5HTR2C gene Ser23 variation with childhood allergic asthma

Published Online: Jul 18, 2022

Page range: 126 - 132

DOI: https://doi.org/10.2478/ebtj-2022-0013

Keywords
Childhood Allergic Asthma, Atopy, rs6318

© 2022 Sehime Gulsun Temel et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Association of the 5HTR2C gene Ser23 variation with childhood allergic asthma

Published Online: Jul 18, 2022

Page range: 126 - 132

DOI: https://doi.org/10.2478/ebtj-2022-0013

KeywordsChildhood Allergic Asthma, Atopy, rs6318

© 2022 Sehime Gulsun Temel et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Childhood Allergic Asthma, Atopy, rs6318