<abstract xmlns="http://www.w3.org/1999/xhtml">

Actovegin® (or Solcoseryl) is a deproteinized hemoderivative of calf’s blood, which contains more than 200 bioactive constituents. Screening and identification of biologically active molecule(s) is challenging due to the complexity of many constituents that may influence various cellular biochemical pathways and are found naturally in the body. Actovegin® comes in different forms including cream, gel, ointment, tablets, and injectable solution. Currently, according to section M2, Chemical and Physical Manipulation of the World Anti-Doping Code, intravenous injections of Actovegin® exceeding 100 ml is prohibited and further serial injections must be at least 12 hours apart. Although the performance-enhancing effects of Actovegin® are still anecdotal, the use of this drug has undoubtedly been widespread in sports for more than two decades. Existing findings provide promising results regarding the effect of Actovegin® in treating muscle injuries at the injected site. Further research exploring other forms of Actovegin ® (tablets, gel, cream) is encouraged to better understand the potential benefits of Actovegin® in applied sports settings.
</abstract>

Actovegin® (or Solcoseryl) is a deproteinized hemoderivative of calf’s blood, which contains more than 200 bioactive constituents. Screening and identification of biologically active molecule(s) is challenging due to the complexity of many constituents that may influence various cellular biochemical pathways and are found naturally in the body. Actovegin® comes in different forms including cream, gel, ointment, tablets, and injectable solution. Currently, according to section M2, Chemical and Physical Manipulation of the World Anti-Doping Code, intravenous injections of Actovegin® exceeding 100 ml is prohibited and further serial injections must be at least 12 hours apart. Although the performance-enhancing effects of Actovegin® are still anecdotal, the use of this drug has undoubtedly been widespread in sports for more than two decades. Existing findings provide promising results regarding the effect of Actovegin® in treating muscle injuries at the injected site. Further research exploring other forms of Actovegin ® (tablets, gel, cream) is encouraged to better understand the potential benefits of Actovegin® in applied sports settings.

The Implications of Actovegin® in Sport: A Brief Review

University of Kragujevac, Faculty of Medical Sciences

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The Implications of Actovegin in Sport: A Brief Review

Actovegin® (or Solcoseryl) is a deproteinized hemoderivative of calf’s blood, which contains more than 200 bioactive constituents. Screening and identification...

The Implications of Actovegin^® in Sport: A Brief Review

Published Online: Mar 23, 2024

Page range: -

Received: Nov 26, 2023

Accepted: Dec 19, 2023

DOI: https://doi.org/10.2478/eabr-2023-0014

Keywords
Doping, hemoderivative of calf’s blood, WADA, muscle injuries

© 2023 Dragana Milovanovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The Implications of Actovegin® in Sport: A Brief Review

Published Online: Mar 23, 2024

Page range: -

Received: Nov 26, 2023

Accepted: Dec 19, 2023

DOI: https://doi.org/10.2478/eabr-2023-0014

KeywordsDoping, hemoderivative of calf’s blood, WADA, muscle injuries

© 2023 Dragana Milovanovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The Implications of Actovegin^® in Sport: A Brief Review

Keywords
Doping, hemoderivative of calf’s blood, WADA, muscle injuries