[1. Wald, N. J., J. Boreham, and A. Bailey: Relative intakes of tar, nicotine, and carbon monoxide from cigarettes of different yields; Thorax 39 (1984) 361–364.]Search in Google Scholar
[2. Russell, M. A., M. J. Jarvis, C. Feyerabend, and Y. Saloojee: Reduction of tar, nicotine and carbon mon-oxide intake in low tar smokers; J. Epidemiol. Com-munity Health 40 (1986) 80–85.]Search in Google Scholar
[3. Benowitz, N. L., S. M. Hall, R. I. Herning, P. Jacob, R. T. Jones, and A. L. Osman: Smokers of low-yield cigarettes do not consume less nicotine; N. Engl. J. Med. 309 (1983) 139–142.]Search in Google Scholar
[4. Benowitz, N. L., P. Jacob, J. T. Bernert, M. Wilson, L. Wang., F. Allen, D. Dempsey: Carcinogen exposure during short-term switching from regular to “light” cigarettes; Cancer Epidemiol. Biomarkers Prev. 14 (2005) 1376–1383.]Search in Google Scholar
[5. Benowitz, N. L.: Compensatory smoking of low yield cigarettes. In: Risk associated with smoking cigarettes with low machine-measured yields of tar and nicotine, edited by D. R. Shopland, D. M. Burns, N. L. Benowitz, and R. H. Amacher. NCI Smoking and Tobacco Con-trol Monograph No. 13. Bethesda, (MD): U. S. NIH, National Cancer Institute, NIH Publication. No. 02-5074 (2001) pp. 39–64.]Search in Google Scholar
[6. Burns, D. M. and N. L. Benowitz.: Public health impli-cations of changes in cigarette design and marketing. In: Risk associated with smoking cigarettes with low machine-measured yields of tar and nicotine, edited by D. R. Shopland, D. M. Burns, N. L. Benowitz and R. H. Amacher; NCI Smoking and Tobacco Control Mono-graph No. 13. Bethesda (MD): U. S. NIH, National Cancer Institute, NIH Publication No. 02-5074 (2001) pp. 1–12.]Search in Google Scholar
[7. Mendes, P., S. Kapur, J. Wang, S. Feng, and H. J. Roethig: A randomized, controlled exposure study in adult smokers of full flavor Marlboro cigarettes swit-ching to Marlboro Lights or Marlboro Ultra Lights cigarettes; Regul. Toxicol. Pharmacol. 51 (2008) 295–305.]Search in Google Scholar
[8. Roethig, H. J., R. D. Kinser, R. W. Lau, R. A. Walk, and N. Wang: Short-term exposure evaluation of adult smokers switching from conventional to first-generation electrically-heated cigarettes during controlled smoking; J. Clin. Pharmacol. 45 (2005) 133–45.]Search in Google Scholar
[9. Scherer, G.: Smoking behavior and compensation: a review of the literature; Psychopharmacology 145 (1999) 1–20.]Search in Google Scholar
[10. Heller, W. D., G. Scherer, J. G. Gostomzyk, J. Stieber, and F. Adlkofer: Cotinine concentration in the serum of smokers within a representative population in Southern Germany measured in 1984/85 and 87/88. Poster presented at the Symposium “Effects of nicotine on biological systems”, Hamburg, Germany, June 28–30, 1990.]Search in Google Scholar
[11. Lynch, C. J. and N. L. Benowitz: Spontaneous cigarette brand switching: Consequences for nicotine and carbon monoxide exposure; Am. J. Public Health 78 (1987) 1191–1194.]Search in Google Scholar
[12. Peach, H., D. M. Hayward, D. R. Ellard, R. W. Morris, and D. Shah: Phlegm production and lung function among cigarette smokers changing tar groups during the 1970s; J. Epidemiol. Community Health 40 (1986) 110–116.]Search in Google Scholar
[13. Mendes, P. E., Q. Liang, K. Frost-Pineda, S. Munjal, H. J. Roethig, and R. A. Walk: The relationship between smoking machine derived tar yields and biomarkers of exposure in adult cigarette smokers in the U. S.; Regul. Toxicol. Pharmacol. 55 (2009) 17–27.]Search in Google Scholar
[14. Roethig, H. J., S. Munjal, S. Feng, Q. Liang, M. Sarkar, R. A. Walk, and P. E. Mendes: Population estimates for biomarkers of exposure to selected cigarette smoke constituents of adult U. S. cigarette smokers; Nicotine Tob. Res. 10 (2009) 1216–25.]Search in Google Scholar
[15. Tobacco Institute Testing Laboratory. Testing Labora-tory Market Sample # 45 Final Report, “Tar “, “Nico-tine “, and Carbon Monoxide Values. Tobacco Institute Testing Laboratory, Rockville, MD, USA 2003.]Search in Google Scholar
[16. United States Federal Trade Commission. “Tar,” Nicotine and Carbon Monoxide of the Smoke of 1294 Varieties of Domestic Cigarettes for the Year 1998. U. S. Federal Trade Commission. Available from: http://www.ftc.gov/reports/tobacco/1998tar&nicotine report.pdf (Accessed on March 20, 2008).]Search in Google Scholar
[17. International Conference on Harmonisation of Techni-cal Requirements for Registration of Pharmaceuticals for Clinical Use. ICH Tripartite guideline for good clinical practice. International Conference on Harmoni-sation. Available at http://www.ich.org/LOB/media/MEDIA482.pdf (Accessed on March 20, 2008).]Search in Google Scholar
[18. World Medical Association. Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. 52nd World Medical Association General Assembly, Edinburgh, Scotland. Available at http://www.wma.net/e/policy/pdf/17c.pdf (Accessed on March 20, 2008).]Search in Google Scholar
[19. Roethig, H. J., B. K. Zedler, R. D. Kinser, S. Feng, B. Nelson, and Q. Liang: Short-term clinical exposure evaluation of a second-generation electrically heated cigarettes smoking system; J. Clin. Pharmacol. 47 (2007) 518–30.]Search in Google Scholar
[20. Sarkar, M., R. Stabbert, R. D. Kinser, J. Oey, K. Rustemeier, K. von Holt, G. Schepers, R. A. Walk, and H. J. Roethig: CYP1A2 and NAT2 phenotyping and 3-aminobiphenyl and 4-aminobiphenyl hemoglobin adduct levels in smokers and non-smokers; Toxicol. Appl. Pharmacol. 213 (2006) 198–206.]Search in Google Scholar
[21. Urban, M., G. Gilch, G. Schepers, E. van Miert, and G. Scherer: Determination of the major mercapturic acids of 1,3-butadiene in human and rat urine using liquid chromatography with tandem mass spectrometry; J. Chromatogr. B 796 (2003) 131–140.]Search in Google Scholar
[22. Zedler, B. K., R. Kinser, J. Oey, B. Nelson, H. J. Roethig, R. A. Walk, P. Kuhl, K. Rustemeier, G. Schepers, K. Von Holt, and R. A. Tricker: Biomarkers of exposure and potential harm in adult smokers of 3–7 mg tar yield (Federal Trade Commission) ciga-rettes and in adult non-smokers; Biomarkers 11 (2006) 201–220.]Search in Google Scholar
[23. Guidance for Industry. Bioanalytical Method Validation. U. S. Department of Health and Human Services and U. S. Food and Drug Administration, 2001. Available from http://www.fda.gov/cder/guidance/4252fnl.pdf (Accessed on March 20, 2008).]Search in Google Scholar
[24. Burtis, C. A. and E. R. Ashwood (Eds.): Tietz Textbook of Clinical Chemistry. W. B. Saunders Company, Philadelphia, 1999.]Search in Google Scholar
[25. Tukey, J. W.: Exploratory data analysis. Reading, MA: Addison-Wesley, 1977, pp 688.]Search in Google Scholar
[26. Fisher, B: Curing the TNSA problem. Tob. Rep. 127 (2000) 51–58.]Search in Google Scholar
[27. Nestor, T. B., J. S. Gentry, D. M. Peele, M. G. Riddick, B. T. Conner, and M. E. Edwards: Role of Oxides of Nitrogen in Tobacco-specific Nitrosamine Formation in Flue-cured Tobacco; Beitr. Tabakforsch. Int. 20 (2003) 467– 475.]Search in Google Scholar
