<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Cigarette smoke condensate (CSC) processed with acetone was found to contain 2,2,6-trimethyl-4-piperidone and the cis and trans isomers of 2,6-dimethyl-4-piperidone. The compounds were found to be artifacts formed by the reaction of the smoke components ammonia and acetaldehyde with the solvent acetone. Conditions which affected the yield of the artifacts from the processed CSC include pH, temperature, reaction time, and levels of ammonia and acetaldehyde present in CSC.</p></abstract>

Cigarette smoke condensate (CSC) processed with acetone was found to contain 2,2,6-trimethyl-4-piperidone and the cis and trans isomers of 2,6-dimethyl-4-piperidone. The compounds were found to be artifacts formed by the reaction of the smoke components ammonia and acetaldehyde with the solvent acetone. Conditions which affected the yield of the artifacts from the processed CSC include pH, temperature, reaction time, and levels of ammonia and acetaldehyde present in CSC.

Isolation and ldentification of 2,6- Dimethyl- and 2,2,6 -Trimethyl-4-piperidone, Artifacts Produced by the Reaction of Cigarette Smoke Condensate and Acetone

Philip Morris Research Center, Richmond, Virginia, U.S.A.

Contributions to Tobacco & Nicotine Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Cigarette smoke condensate (CSC) processed with acetone was found to contain 2,2,6-trimethyl-4-piperidone and the cis and trans isomers of...

Isolation and ldentification of 2,6- Dimethyl- and 2,2,6 -Trimethyl-4-piperidone, Artifacts Produced by the Reaction of Cigarette Smoke Condensate and Acetone

Published Online: Aug 14, 2014

Page range: 208 - 213

DOI: https://doi.org/10.2478/cttr-2013-0449

© Beiträge zur Tabakforschung International

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.