<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Glucagon-like peptide 1 is a neuromodulatory peptide that regulates the carbohydrate metabolism. It can cross the blood-brain barrier, and, indeed, while mostly produced in the distal small intestine and colon, it is also synthesized in the nucleus of the solitary tract of the brain stem. The wide distribution of glucagon-like peptide 1 receptors in the different areas of the brain is responsible for the pleiotropic effects of glucagon-like peptide 1 in the central nervous system. Notably, the peptide plays important roles in regulating food intake, in memory functioning, as well as in neuroprotective processes and emotions. This makes it an important tool in the treatment of many central nervous system related abnormalities, such as neurodegenerative diseases, addictions and neuropsychiatric disorders.</p>
</abstract>

Glucagon-like peptide 1 is a neuromodulatory peptide that regulates the carbohydrate metabolism. It can cross the blood-brain barrier, and, indeed, while mostly produced in the distal small intestine and colon, it is also synthesized in the nucleus of the solitary tract of the brain stem. The wide distribution of glucagon-like peptide 1 receptors in the different areas of the brain is responsible for the pleiotropic effects of glucagon-like peptide 1 in the central nervous system. Notably, the peptide plays important roles in regulating food intake, in memory functioning, as well as in neuroprotective processes and emotions. This makes it an important tool in the treatment of many central nervous system related abnormalities, such as neurodegenerative diseases, addictions and neuropsychiatric disorders.

New perspectives on the use of glucagon-like peptide 1 in diseases of the central nervous system

Department of Experimental and Clinical Pharmacology

Department of Pharmacology and Pharmacodynamics

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Glucagon-like peptide 1 is a neuromodulatory peptide that regulates the carbohydrate metabolism. It can cross the blood-brain barrier, and, indeed, while...

New perspectives on the use of glucagon-like peptide 1 in diseases of the central nervous system

Published Online: Dec 25, 2023

Page range: 232 - 235

Received: Sep 22, 2023

Accepted: Oct 16, 2023

DOI: https://doi.org/10.2478/cipms-2023-0040

Keywords
addiction, Parkinson disease, Alzheimer disease, glucagon-like peptide 1, neuroprotective effects, anti-inflammatory effects

© 2023 Malgorzata Lupina et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

New perspectives on the use of glucagon-like peptide 1 in diseases of the central nervous system

Published Online: Dec 25, 2023

Page range: 232 - 235

Received: Sep 22, 2023

Accepted: Oct 16, 2023

DOI: https://doi.org/10.2478/cipms-2023-0040

Keywordsaddiction, Parkinson disease, Alzheimer disease, glucagon-like peptide 1, neuroprotective effects, anti-inflammatory effects

© 2023 Malgorzata Lupina et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
addiction, Parkinson disease, Alzheimer disease, glucagon-like peptide 1, neuroprotective effects, anti-inflammatory effects