<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>In this work, analysis of some drugs used in the treatment of neurodegenerative disorders (sulpiride, olanzapine, carbamazepine, trazodone, clomipramine, and pridinol) was achieved through micellar electrokinetic chromatography (MEKC). The effect of surfactant (sodium dodecylsulphate), acetonitrile, and buffer pH and concentration on the solute retention was also investigated. Successful separation of all compound mixtures was obtained. The method was applied for the quantitative analysis of investigated compounds, and the LOD and LOQ were determined. The LOD values were in the range from 0.0127 mg/mL for clomipramine, to 0.1398 mg/mL for pridinol, while LOQ were in the range 0.0384 mg/mL for clomipramine, to 0.4237 for pridinol. The mode was also applied for the determination of investigated solutes in pharmaceutical prescriptions.</p>
</abstract>

In this work, analysis of some drugs used in the treatment of neurodegenerative disorders (sulpiride, olanzapine, carbamazepine, trazodone, clomipramine, and pridinol) was achieved through micellar electrokinetic chromatography (MEKC). The effect of surfactant (sodium dodecylsulphate), acetonitrile, and buffer pH and concentration on the solute retention was also investigated. Successful separation of all compound mixtures was obtained. The method was applied for the quantitative analysis of investigated compounds, and the LOD and LOQ were determined. The LOD values were in the range from 0.0127 mg/mL for clomipramine, to 0.1398 mg/mL for pridinol, while LOQ were in the range 0.0384 mg/mL for clomipramine, to 0.4237 for pridinol. The mode was also applied for the determination of investigated solutes in pharmaceutical prescriptions.

Determination of some drugs used against neurodegenerative disorders by micellar electrokinetic chromatography with running buffer containing SDS

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

In this work, analysis of some drugs used in the treatment of neurodegenerative disorders (sulpiride, olanzapine, carbamazepine, trazodone, clomipramine, and...

Determination of some drugs used against neurodegenerative disorders by micellar electrokinetic chromatography with running buffer containing SDS

Published Online: Jun 30, 2023

Page range: 121 - 127

Received: May 17, 2023

Accepted: Jun 04, 2023

DOI: https://doi.org/10.2478/cipms-2023-0021

Keywords
separation, drugs analysis, micellar electrokinetic chromatography, sodium dodecyl sulphate

© 2023 Adam Traczuk et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Determination of some drugs used against neurodegenerative disorders by micellar electrokinetic chromatography with running buffer containing SDS

Published Online: Jun 30, 2023

Page range: 121 - 127

Received: May 17, 2023

Accepted: Jun 04, 2023

DOI: https://doi.org/10.2478/cipms-2023-0021

Keywordsseparation, drugs analysis, micellar electrokinetic chromatography, sodium dodecyl sulphate

© 2023 Adam Traczuk et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
separation, drugs analysis, micellar electrokinetic chromatography, sodium dodecyl sulphate