<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Liver damage is a common problem around the world, and pharmacocorrection of such disease is carried out by administration of various drugs. Natural and synthetic thio-containing compounds are important in this respect. Most of these, however, have side effects and do not always meet the criteria of evidence-based medicine. Therefore, the search for new drugs with hepatoprotective properties, characterized by high efficiency and low toxicity, is an urgent problem of current pharmacology and biochemistry. The purpose of this study was to assess the acute toxicity of new potentially bioactive S-substituted pteridinones, to select the least toxic substance, to improve the pharmaco-technological characteristics, and to study the hepatoprotective properties in an experimental model of tetrachloromethane hepatitis in rats. Herein, comparison of the hepatoprotective properties of compound 4.1 and the reference drug "Thiotriazoline" is based on biochemical studies. The research results showed that sub-stance 4.1 had a positive effect on biochemical processes by increasing the compensatory mechanisms of antioxidant systems, while reducing the infiltrative, destructive and inflamma-tory process in the liver, evoking decreases in the cytolytic process, restoring the structure of the components of the membrane of hepatocytes, stabilizing and enhancing the functional activity of the liver, restoring the liver’s protein-synthesizing function and increasing the abil-ity to restore metabolic disorders in the liver. As a result of the biochemical study of the hepa-toprotective effect of compound 4.1, it was found that the studied substance is a non-toxic compound with antioxidant properties.</p>
</abstract>

Liver damage is a common problem around the world, and pharmacocorrection of such disease is carried out by administration of various drugs. Natural and synthetic thio-containing compounds are important in this respect. Most of these, however, have side effects and do not always meet the criteria of evidence-based medicine. Therefore, the search for new drugs with hepatoprotective properties, characterized by high efficiency and low toxicity, is an urgent problem of current pharmacology and biochemistry. The purpose of this study was to assess the acute toxicity of new potentially bioactive S-substituted pteridinones, to select the least toxic substance, to improve the pharmaco-technological characteristics, and to study the hepatoprotective properties in an experimental model of tetrachloromethane hepatitis in rats. Herein, comparison of the hepatoprotective properties of compound 4.1 and the reference drug "Thiotriazoline" is based on biochemical studies. The research results showed that sub-stance 4.1 had a positive effect on biochemical processes by increasing the compensatory mechanisms of antioxidant systems, while reducing the infiltrative, destructive and inflamma-tory process in the liver, evoking decreases in the cytolytic process, restoring the structure of the components of the membrane of hepatocytes, stabilizing and enhancing the functional activity of the liver, restoring the liver’s protein-synthesizing function and increasing the abil-ity to restore metabolic disorders in the liver. As a result of the biochemical study of the hepa-toprotective effect of compound 4.1, it was found that the studied substance is a non-toxic compound with antioxidant properties.

Evaluation of the toxicity and hepatoprotective properties of new s-substituted pteridins

Department of Physiology, Immunology, Biochemistry with a course in Civil Defense and Medicine

Department of Pharmacognosy, Pharmaceutical Chemistry and Medicinal Preparations Technology

Department of Organic and Bioorganic Chemistry

Department of Composite Materials, Chemistry and Technology

National University "Zaporizhzhia Polytechnic"

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Liver damage is a common problem around the world, and pharmacocorrection of such disease is carried out by administration of various drugs. Natural and...

Evaluation of the toxicity and hepatoprotective properties of new s-substituted pteridins

Published Online: May 01, 2023

Page range: 21 - 26

Received: Dec 14, 2022

Accepted: Feb 08, 2023

DOI: https://doi.org/10.2478/cipms-2023-0006

Keywords
toxic liver damage, S-substituted pteridines, acute toxicity, hepatoprotective and antioxidant properties

© 2023 Natalya Groma et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Evaluation of the toxicity and hepatoprotective properties of new s-substituted pteridins

Published Online: May 01, 2023

Page range: 21 - 26

Received: Dec 14, 2022

Accepted: Feb 08, 2023

DOI: https://doi.org/10.2478/cipms-2023-0006

Keywordstoxic liver damage, S-substituted pteridines, acute toxicity, hepatoprotective and antioxidant properties

© 2023 Natalya Groma et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
toxic liver damage, S-substituted pteridines, acute toxicity, hepatoprotective and antioxidant properties