<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The process of epithelial-mesenchymal transition (EMT) occurs in both physiological and pathological states, and there are increasing links between EMT and tumor progression. During this process, dynamic changes in cell organization and function occur that promote migration and invasion. A better understanding of the mechanism of plastic EMT may help develop novel targeted therapies that can help treat cancers of varying degrees of malignancy. Our review helps to systematize knowledge of the molecular and biochemical mechanisms involved in the EMT process in both tumor and physiological backgrounds.</p>
</abstract>

The process of epithelial-mesenchymal transition (EMT) occurs in both physiological and pathological states, and there are increasing links between EMT and tumor progression. During this process, dynamic changes in cell organization and function occur that promote migration and invasion. A better understanding of the mechanism of plastic EMT may help develop novel targeted therapies that can help treat cancers of varying degrees of malignancy. Our review helps to systematize knowledge of the molecular and biochemical mechanisms involved in the EMT process in both tumor and physiological backgrounds.

Epithelial-mesenchymal transition

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Epithelial-mesenchymal transition"}

The process of epithelial-mesenchymal transition (EMT) occurs in both physiological and pathological states, and there are increasing links between EMT and...

Epithelial-mesenchymal transition

Published Online: May 01, 2023

Page range: 18 - 20

Received: Dec 06, 2022

Accepted: Mar 03, 2023

DOI: https://doi.org/10.2478/cipms-2023-0005

Keywords
epithelial-mesenchymal transition, cancer metastasis, circulating tumor cells, epithelial markers

© 2023 Joanna Kubik et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Epithelial-mesenchymal transition

Published Online: May 01, 2023

Page range: 18 - 20

Received: Dec 06, 2022

Accepted: Mar 03, 2023

DOI: https://doi.org/10.2478/cipms-2023-0005

Keywordsepithelial-mesenchymal transition, cancer metastasis, circulating tumor cells, epithelial markers

© 2023 Joanna Kubik et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
epithelial-mesenchymal transition, cancer metastasis, circulating tumor cells, epithelial markers