<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human Epstein-Barr (EBV) and Papillomavirus-(HPV) related cancers. These viruses are able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation. The aim of the study is to review current data and summarize knowledge on the TLRs and their role in the development of cancer, especially viral-related cancers (EBV and HPV). Research work shows a correlation between the TLRs polymorphism and the development of oropharyngeal and gastric cancer (GC), especially related to viral infections. Many studies suggest the important role for TLRs in inflammatory, autoimmune disease and human cancers. However, further efforts are necessary to draw a precise conclusion.</p>
</abstract>

The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human Epstein-Barr (EBV) and Papillomavirus-(HPV) related cancers. These viruses are able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation. The aim of the study is to review current data and summarize knowledge on the TLRs and their role in the development of cancer, especially viral-related cancers (EBV and HPV). Research work shows a correlation between the TLRs polymorphism and the development of oropharyngeal and gastric cancer (GC), especially related to viral infections. Many studies suggest the important role for TLRs in inflammatory, autoimmune disease and human cancers. However, further efforts are necessary to draw a precise conclusion.

The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review"}

The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human Epstein-Barr (EBV) and...

The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review

Published Online: Jan 29, 2021

Page range: 225 - 227

Received: Feb 21, 2020

Accepted: Jul 16, 2020

DOI: https://doi.org/10.2478/cipms-2020-0038

Keywords
TLR9, EBV, HPV, nasopharyngeal cancer, gastric cancer

© 2020 Anna Dworzanska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review

Published Online: Jan 29, 2021

Page range: 225 - 227

Received: Feb 21, 2020

Accepted: Jul 16, 2020

DOI: https://doi.org/10.2478/cipms-2020-0038

KeywordsTLR9, EBV, HPV, nasopharyngeal cancer, gastric cancer

© 2020 Anna Dworzanska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
TLR9, EBV, HPV, nasopharyngeal cancer, gastric cancer