<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>We earlier reported the protective effect of <italic>Solanum dasyphyllum</italic> against cyanide neurotoxicity. In furtherance to this, we investigated the protective effect of <italic>S. dasyphyllum</italic> against rotenone, a chemical toxin that causes brain-related diseases. Mitochondria fraction obtained from the brain of male Wistar rats was incubated with various solvents (hexane, dichloromethane, ethylacetate, and methanol) extracts of <italic>S. dasyphyllum</italic> before rotenone exposure. Mitochondria respiratory enzymes (MRE) were evaluated along with markers of oxidative stress. The inhibition of MRE by rotenone was reversed by treatment with various fractions of <italic>S. dasyphyllum</italic>. The oxidative stress induced by rotenone was also reversed by fractions of <italic>S. dasyphyllum</italic>. In addition, the ethylacetate fraction of <italic>S. dasyphyllum</italic> was most potent against rotenone-induced neurotoxicity. In conclusion, <italic>S. dasyphyllum</italic> is rich in active phytochemicals that can prevent some neurotoxic effects of rotenone exposure. Further study can be done in an in vivo model to substantiate our results.</p>
</abstract>

We earlier reported the protective effect of Solanum dasyphyllum against cyanide neurotoxicity. In furtherance to this, we investigated the protective effect of S. dasyphyllum against rotenone, a chemical toxin that causes brain-related diseases. Mitochondria fraction obtained from the brain of male Wistar rats was incubated with various solvents (hexane, dichloromethane, ethylacetate, and methanol) extracts of S. dasyphyllum before rotenone exposure. Mitochondria respiratory enzymes (MRE) were evaluated along with markers of oxidative stress. The inhibition of MRE by rotenone was reversed by treatment with various fractions of S. dasyphyllum. The oxidative stress induced by rotenone was also reversed by fractions of S. dasyphyllum. In addition, the ethylacetate fraction of S. dasyphyllum was most potent against rotenone-induced neurotoxicity. In conclusion, S. dasyphyllum is rich in active phytochemicals that can prevent some neurotoxic effects of rotenone exposure. Further study can be done in an in vivo model to substantiate our results.

Reversal effect of <italic>Solanum dasyphyllum</italic> against rotenone-induced neurotoxicity

Department of Biochemistry, School of Sciences

Department of Biochemistry, Faculty of Science

Department of Biochemistry, Faculty of Life Sciences

Department of Biochemistry, Faculty of Natural Sciences

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Reversal effect of  against rotenone-induced neurotoxicity

We earlier reported the protective effect of Solanum dasyphyllum against cyanide neurotoxicity. In furtherance to this, we investigated the protective effect...

Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity

Published Online: Jan 29, 2021

Page range: 191 - 196

Received: Feb 17, 2020

Accepted: Jun 04, 2020

DOI: https://doi.org/10.2478/cipms-2020-0034

Keywords
rotenone, mitochondria respiratory enzymes, oxidative stress, Solanum dasyphyllum, brain

© 2020 Omotayo B. Ilesanmi et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Reversal effect of Solanum dasyphyllum against rotenone-induced neurotoxicity

Published Online: Jan 29, 2021

Page range: 191 - 196

Received: Feb 17, 2020

Accepted: Jun 04, 2020

DOI: https://doi.org/10.2478/cipms-2020-0034

Keywordsrotenone, mitochondria respiratory enzymes, oxidative stress, Solanum dasyphyllum, brain

© 2020 Omotayo B. Ilesanmi et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
rotenone, mitochondria respiratory enzymes, oxidative stress, Solanum dasyphyllum, brain