<abstract xmlns="http://www.w3.org/1999/xhtml"><p>In previous studies of actoprotective activity of 5-R-thio-tetrazolo[1,5]quinazoline derivatives in normal and complicated experimental conditions, sodium 2-(tetrazolo [1,5-c]quinazoline-5-ylthio)acetate (KB-28) was found to be the leader of the experiment. The objective of the current study was to characterize the effects of KB-28 compounds on carbohydrate and lipid exchange indices under the conditions of physical load as a possible mechanism of actoprotective effect. In the course of the experiment, the indices of carbohydrate and lipid exchange in the muscle, blood and liver of animal models were determined following a 15-day physical load course. In doing so, glucose, glycogen and total lipid concentrations were assessed. The KB-28 compound was administered daily at levels determined during the course of regular physical load normalized metabolic processes in rats. The results were then compared to a control which received intraperitoneally the equivolume 0.9% sodium chloride solution. The phenomenon of actoprotection consisted in enhancing concentrations of glycogen in skeletal muscles and liver. Compared to the control figures, this increase was 28.8% and 25.0%, accordingly. Moreover, the course of KB-28 caused a statistically significant reduction (by 32.1%) of the total serum lipid concentration in the animals under physical load. The effect may be a sign of the ability of this substance to utilize active lipolysis for improvement of the skeletal muscle performance. Having analyzed the results obtained, we can draw a conclusion that influencing the biochemical processes in the study models is one of the mechanisms of the KB-28 actoprotective effect.</p></abstract>

In previous studies of actoprotective activity of 5-R-thio-tetrazolo[1,5]quinazoline derivatives in normal and complicated experimental conditions, sodium 2-(tetrazolo [1,5-c]quinazoline-5-ylthio)acetate (KB-28) was found to be the leader of the experiment. The objective of the current study was to characterize the effects of KB-28 compounds on carbohydrate and lipid exchange indices under the conditions of physical load as a possible mechanism of actoprotective effect. In the course of the experiment, the indices of carbohydrate and lipid exchange in the muscle, blood and liver of animal models were determined following a 15-day physical load course. In doing so, glucose, glycogen and total lipid concentrations were assessed. The KB-28 compound was administered daily at levels determined during the course of regular physical load normalized metabolic processes in rats. The results were then compared to a control which received intraperitoneally the equivolume 0.9% sodium chloride solution. The phenomenon of actoprotection consisted in enhancing concentrations of glycogen in skeletal muscles and liver. Compared to the control figures, this increase was 28.8% and 25.0%, accordingly. Moreover, the course of KB-28 caused a statistically significant reduction (by 32.1%) of the total serum lipid concentration in the animals under physical load. The effect may be a sign of the ability of this substance to utilize active lipolysis for improvement of the skeletal muscle performance. Having analyzed the results obtained, we can draw a conclusion that influencing the biochemical processes in the study models is one of the mechanisms of the KB-28 actoprotective effect.

Biochemical aspects of KB-28 compound on physically loaded study subjects

National Pirogov Memorial Medical University

Department of Biological and General Chemistry

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Biochemical aspects of KB-28 compound on physically loaded study subjects"}

In previous studies of actoprotective activity of 5-R-thio-tetrazolo[1,5]quinazoline derivatives in normal and complicated experimental conditions, sodium...

Biochemical aspects of KB-28 compound on physically loaded study subjects

Published Online: Sep 28, 2019

Page range: 168 - 172

Received: Dec 27, 2018

Accepted: Apr 03, 2019

DOI: https://doi.org/10.2478/cipms-2019-0030

Keywords
acute lymphoblastic leukemia, physical endurance, carbohydrate metabolism, lipid metabolism, 2-ethylthiobenzimidazole hydrobromide, sodium 2-(tetrazolo[1,5-c] quinazoline-5-ylthio)acetate

© 2019 Olena Toziuk et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Biochemical aspects of KB-28 compound on physically loaded study subjects

Published Online: Sep 28, 2019

Page range: 168 - 172

Received: Dec 27, 2018

Accepted: Apr 03, 2019

DOI: https://doi.org/10.2478/cipms-2019-0030

Keywordsacute lymphoblastic leukemia, physical endurance, carbohydrate metabolism, lipid metabolism, 2-ethylthiobenzimidazole hydrobromide, sodium 2-(tetrazolo[1,5-c] quinazoline-5-ylthio)acetate

© 2019 Olena Toziuk et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
acute lymphoblastic leukemia, physical endurance, carbohydrate metabolism, lipid metabolism, 2-ethylthiobenzimidazole hydrobromide, sodium 2-(tetrazolo[1,5-c] quinazoline-5-ylthio)acetate