<abstract xmlns="http://www.w3.org/1999/xhtml">The estrogenic activities of fenugreek seeds (<italic>Trigonella foenum-graecum L</italic>.), widely used in traditional pharmacopoeia, are reflected in the uterus of ovariectomized female rats, with a slight increase in dry and wet weight, a thickening of the stroma and the uterine epithelium and the development of the endometrial glands. In the vagina, the estrogenic action is shown through an increase in the epidermal cell number and a tendency to keratinization, leading to vaginal opening.Furthermore, this estrogenic potential of fenugreek seeds is confirmed by the over-expression of progesterone receptors in the uterine tissues supporting possible interactions between phytoestrogens and estrogen receptors.Therefore, Fenugreek seeds may be capable of promoting the development of reproductive tissues of immature ovariectomized rats, and its estrogenic activity may take its action by holding phystoestrogens that interact with estrogen binding sites and activate the same estradiol-mediated cell signaling pathways.Thus, our results give added scientific support to the popular use of Fenugreek seeds as an alternative for several health problems such as fertility and menopause related disorders.</abstract>

The estrogenic activities of fenugreek seeds (Trigonella foenum-graecum L.), widely used in traditional pharmacopoeia, are reflected in the uterus of ovariectomized female rats, with a slight increase in dry and wet weight, a thickening of the stroma and the uterine epithelium and the development of the endometrial glands. In the vagina, the estrogenic action is shown through an increase in the epidermal cell number and a tendency to keratinization, leading to vaginal opening.Furthermore, this estrogenic potential of fenugreek seeds is confirmed by the over-expression of progesterone receptors in the uterine tissues supporting possible interactions between phytoestrogens and estrogen receptors.Therefore, Fenugreek seeds may be capable of promoting the development of reproductive tissues of immature ovariectomized rats, and its estrogenic activity may take its action by holding phystoestrogens that interact with estrogen binding sites and activate the same estradiol-mediated cell signaling pathways.Thus, our results give added scientific support to the popular use of Fenugreek seeds as an alternative for several health problems such as fertility and menopause related disorders.

Fenugreek seeds estrogenic activity in ovariectomized female rats

Research Unit Associate CNRST – URAC 34, Faculty of Sciences Ben M’Sik

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Fenugreek seeds estrogenic activity in ovariectomized female rats"}

The estrogenic activities of fenugreek seeds (Trigonella foenum-graecum L.), widely used in traditional pharmacopoeia, are reflected in the uterus of...

Fenugreek seeds estrogenic activity in ovariectomized female rats

Published Online: Sep 28, 2019

Page range: 138 - 145

Received: Dec 08, 2018

Accepted: Feb 21, 2019

DOI: https://doi.org/10.2478/cipms-2019-0026

Keywords
fenugreek, estrogenic effect, phytoestrogens, ovariectomized rats, progesterone receptors

© 2019 Hind Brogi et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Fenugreek seeds estrogenic activity in ovariectomized female rats

Published Online: Sep 28, 2019

Page range: 138 - 145

Received: Dec 08, 2018

Accepted: Feb 21, 2019

DOI: https://doi.org/10.2478/cipms-2019-0026

Keywordsfenugreek, estrogenic effect, phytoestrogens, ovariectomized rats, progesterone receptors

© 2019 Hind Brogi et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
fenugreek, estrogenic effect, phytoestrogens, ovariectomized rats, progesterone receptors