<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Pain is a symptom of many diseases and significantly affects the quality of life, so researchers are constantly seeking new substances to be used as analgesics. Other, easier way is to combine already known drugs which cause synergistic effects greater than additive, so that probability of drug-specific side effects can be reduced. Researchers showed that caffeine can be an effective analgesic adjuvant enhancing antinociceptive effect of ibuprofen in animals and humans. By using modern drug technology methods tablets containing well-soluble ibuprofen salt and caffeine can be easily prepared. Thanks to that combination, the therapeutic dose of ibuprofen can be lowered and the side effects may be reduced.</p></abstract>

Pain is a symptom of many diseases and significantly affects the quality of life, so researchers are constantly seeking new substances to be used as analgesics. Other, easier way is to combine already known drugs which cause synergistic effects greater than additive, so that probability of drug-specific side effects can be reduced. Researchers showed that caffeine can be an effective analgesic adjuvant enhancing antinociceptive effect of ibuprofen in animals and humans. By using modern drug technology methods tablets containing well-soluble ibuprofen salt and caffeine can be easily prepared. Thanks to that combination, the therapeutic dose of ibuprofen can be lowered and the side effects may be reduced.

Review on analgesic effect of co-administrated ibuprofen and caffeine

Department of Applied Pharmacy, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland

Department of Organic Chemistry, Medical University of Lublin, Poland

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Review on analgesic effect of co-administrated ibuprofen and caffeine"}

Pain is a symptom of many diseases and significantly affects the quality of life, so researchers are constantly seeking new substances to be used as...

Review on analgesic effect of co-administrated ibuprofen and caffeine

Published Online: May 30, 2014

Page range: 10 - 13

Received: Dec 06, 2013

Accepted: Feb 14, 2014

DOI: https://doi.org/10.2478/cipms-2014-0003

Keywords
analgesic, caffeine, ibuprofen, tablets

© 2014

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Review on analgesic effect of co-administrated ibuprofen and caffeine

Published Online: May 30, 2014

Page range: 10 - 13

Received: Dec 06, 2013

Accepted: Feb 14, 2014

DOI: https://doi.org/10.2478/cipms-2014-0003

Keywordsanalgesic, caffeine, ibuprofen, tablets

© 2014

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
analgesic, caffeine, ibuprofen, tablets