<abstract xmlns="http://www.w3.org/1999/xhtml"><p><italic>CDH1</italic> is currently the only gene in which mutations are known to cause hereditary diffuse gastric cancer (HDGC). Hereditary diffuse gastric cancer is defined as a syndrome of inherited predisposition to cancer with autosomal dominant inheritance pattern. Specific criteria are used to identify patients with suspected HDGC and who should be investigated for <italic>CDH1</italic> germline mutations. Accurate screening is mandatory for unaffected carriers of<italic>CDH1</italic> mutations and selected high-risk individuals could be considered for prophylactic gastrectomy.</p></abstract>

CDH1 is currently the only gene in which mutations are known to cause hereditary diffuse gastric cancer (HDGC). Hereditary diffuse gastric cancer is defined as a syndrome of inherited predisposition to cancer with autosomal dominant inheritance pattern. Specific criteria are used to identify patients with suspected HDGC and who should be investigated for CDH1 germline mutations. Accurate screening is mandatory for unaffected carriers ofCDH1 mutations and selected high-risk individuals could be considered for prophylactic gastrectomy.

<italic>CDH1</italic> Mutation in Two Patients with Hereditary Gastric Cancer

Pauls Stradins Clinical University Hospital, Riga, Latvia

Institute of Oncology, Riga Stradins University, Latvia

Acta Chirurgica Latviensis

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

 Mutation in Two Patients with Hereditary Gastric Cancer

CDH1 is currently the only gene in which mutations are known to cause hereditary diffuse gastric cancer (HDGC). Hereditary diffuse gastric cancer is defined as...

CDH1 Mutation in Two Patients with Hereditary Gastric Cancer

Article Category: Case Report

Published Online: Nov 24, 2014

Page range: 35 - 37

DOI: https://doi.org/10.2478/chilat-2014-0107

Keywords
gastric cancer, hereditary diffuse gastric cancer,

© 2014 Jelena Pogodina et. al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

CDH1 Mutation in Two Patients with Hereditary Gastric Cancer

Article Category: Case Report

Published Online: Nov 24, 2014

Page range: 35 - 37

DOI: https://doi.org/10.2478/chilat-2014-0107

Keywordsgastric cancer, hereditary diffuse gastric cancer,

© 2014 Jelena Pogodina et. al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
gastric cancer, hereditary diffuse gastric cancer,