<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The aim of the study was to examine the genotype-allele determination of <italic>CYP1A2</italic> rs2069514 and rs762551 polymorphisms in patients with mild and severe COVID-19 and to determine their effectiveness as prognostic criteria in COVID-19. The study consists of 60 patients who were hospitalized in intensive care or outpatient treatment due to COVID-19 in Istanbul NP Brain Hospital between 2020–2021. Genotyping was conducted by Real-Time PCR. Age (p&lt;0.001); chronic disease (p=0.002); cardiovascular disease (p=0.004); respiratory distress (p&lt;0.001); neurological disease (p=0.004); fatigue (p=0.048); loss of taste and smell (p=0.003); nausea/vomiting (p=0.026); intubated (p&lt;0.001); ground glass image (p&lt;0.001) and <italic>CYP1A2</italic> genotypes (p&lt;0.001) showed a statistically significant difference between patients with and without intensive care admission. According to multivariate logistic regression analysis, <italic>CYP1A2</italic> *1A/*1C + *1C/*1C genotypes (OR:5.23 95% CI: 1.22–22.36; p=0.025), chronic disease (OR:4.68 95% CI:1.14–19.15; p=0.032) or patients at 65 years or older (OR:5.17, 95%CI:1.26–21.14; p=0.022) increased the risk of admission to the intensive care unit. According to our results, we strongly suggest considering the <italic>CYP1A2</italic> rs2069514 and rs762551 polymorphisms as important predictors of Intensive Care Unit admission in patients with COVID-19, and we also suggest that genotype results will guide clinicians for the benefit and the efficiency of the treatment.</p>
</abstract>

The aim of the study was to examine the genotype-allele determination of CYP1A2 rs2069514 and rs762551 polymorphisms in patients with mild and severe COVID-19 and to determine their effectiveness as prognostic criteria in COVID-19. The study consists of 60 patients who were hospitalized in intensive care or outpatient treatment due to COVID-19 in Istanbul NP Brain Hospital between 2020–2021. Genotyping was conducted by Real-Time PCR. Age (p<0.001); chronic disease (p=0.002); cardiovascular disease (p=0.004); respiratory distress (p<0.001); neurological disease (p=0.004); fatigue (p=0.048); loss of taste and smell (p=0.003); nausea/vomiting (p=0.026); intubated (p<0.001); ground glass image (p<0.001) and CYP1A2 genotypes (p<0.001) showed a statistically significant difference between patients with and without intensive care admission. According to multivariate logistic regression analysis, CYP1A2 *1A/*1C + *1C/*1C genotypes (OR:5.23 95% CI: 1.22–22.36; p=0.025), chronic disease (OR:4.68 95% CI:1.14–19.15; p=0.032) or patients at 65 years or older (OR:5.17, 95%CI:1.26–21.14; p=0.022) increased the risk of admission to the intensive care unit. According to our results, we strongly suggest considering the CYP1A2 rs2069514 and rs762551 polymorphisms as important predictors of Intensive Care Unit admission in patients with COVID-19, and we also suggest that genotype results will guide clinicians for the benefit and the efficiency of the treatment.

Prognostic Value of <italic>CYP1A2</italic> (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients

Department of Medical Biochemistry, Faculty of Medicine

Department of Medical Genetics and Molecular Diagnostic Laboratory, Faculty of Medicine

Department of Medical Biology and Genetics, Faculty of Dentistry

Balkan Journal of Medical Genetics

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Prognostic Value of  (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients

The aim of the study was to examine the genotype-allele determination of CYP1A2 rs2069514 and rs762551 polymorphisms in patients with mild and severe COVID-19...

Prognostic Value of CYP1A2 (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients

Article Category: Original Article

Published Online: Jul 31, 2023

Page range: 35 - 42

DOI: https://doi.org/10.2478/bjmg-2023-0005

Keywords
COVID-19, prognosis, hypoxia, CYP1A2, polymorphism

© 2023 I Bozkurt et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Prognostic Value of CYP1A2 (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients

Article Category: Original Article

Published Online: Jul 31, 2023

Page range: 35 - 42

DOI: https://doi.org/10.2478/bjmg-2023-0005

KeywordsCOVID-19, prognosis, hypoxia, CYP1A2, polymorphism

© 2023 I Bozkurt et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
COVID-19, prognosis, hypoxia, CYP1A2, polymorphism