<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Broadband dielectric spectroscopy (BDS) is a method of characterizing matter from the perspective of its dielectric parameters, which varies depending on the frequency of the applied electromagnetic field. During recent years, along with its many uses, there has been an increase in interest in the use of the method in biomedical fields, especially for the characterization of normal and tumor cells. In this context, this review aims to address in the first part the theoretical bases and mathematical models that explain the principle of operation of the broadband spectroscope. Subsequently, the advantages and limitations of the method are detailed, including the difficulties that the researcher may encounter in the case of working with living cells. Finally, the most important scientific results obtained on normal and pathological cell cultures are presented, possible future research directions being suggested.</p>
</abstract>

Broadband dielectric spectroscopy (BDS) is a method of characterizing matter from the perspective of its dielectric parameters, which varies depending on the frequency of the applied electromagnetic field. During recent years, along with its many uses, there has been an increase in interest in the use of the method in biomedical fields, especially for the characterization of normal and tumor cells. In this context, this review aims to address in the first part the theoretical bases and mathematical models that explain the principle of operation of the broadband spectroscope. Subsequently, the advantages and limitations of the method are detailed, including the difficulties that the researcher may encounter in the case of working with living cells. Finally, the most important scientific results obtained on normal and pathological cell cultures are presented, possible future research directions being suggested.

Broadband Dielectric Spectroscopy and Its Role in the Characterization of Biological Cells

University of Medicine and Pharmacy “Gr. T. Popa” Iași

“Gheorghe Asachi” Technical University of Iaşi

Bulletin of the Polytechnic Institute of Iași. Electrical Engineering, Power Engineering, Electronics Section

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Broadband dielectric spectroscopy (BDS) is a method of characterizing matter from the perspective of its dielectric parameters, which varies depending on the...

Broadband Dielectric Spectroscopy and Its Role in the Characterization of Biological Cells

Published Online: Feb 18, 2022

Page range: 9 - 20

Received: Sep 13, 2021

Accepted: Oct 15, 2021

DOI: https://doi.org/10.2478/bipie-2021-0001

Keywords
Broadband dielectric spectroscopy, tumor cells, dielectric parameters, spectrometer, Nyquist plot

© 2021 Thomas Gabriel Schreiner et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Broadband Dielectric Spectroscopy and Its Role in the Characterization of Biological Cells

Published Online: Feb 18, 2022

Page range: 9 - 20

Received: Sep 13, 2021

Accepted: Oct 15, 2021

DOI: https://doi.org/10.2478/bipie-2021-0001

KeywordsBroadband dielectric spectroscopy, tumor cells, dielectric parameters, spectrometer, Nyquist plot

© 2021 Thomas Gabriel Schreiner et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Broadband dielectric spectroscopy, tumor cells, dielectric parameters, spectrometer, Nyquist plot