<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>This study investigated the effects of dietary inclusion of grape seed meal (GSM) on antioxidant markers in kidney of aflatoxin B1 fed pigs. Twenty-four cross-bred pigs (TOPIG-40) were randomly assigned to one of the four experimental diets: control (Control), aflatoxin B1 (diet contaminated with 320 μg AFB1/kg feed), grape seed meal (diet with 8% GSM) and AFB1+GSM (320 μg AFB1/kg feed + 8% GSM) for 30 days. Aflatoxin B1 induced oxidative damage and showed lower antioxidant status in kidney after 30 days. CAT and SOD activity measured in kidneys revealed significant differences when comparing the GSM+AFB1 group with the AFB1 group. Additionally, GSM diet alone did not affect CAT and SOD levels in kidneys of piglets compared with the control group, suggesting that they are maintained at physiological levels. We did not detect any effects of GSM on GPx and TAS. Including GSM into piglets’ diet significantly lowered lipid peroxidation induced by AFB1, while it did not affect it compared with the control group. The present study demonstrated the ability of GSM to alleviate the effects induced by the toxin evidenced by the improvement in the antioxidant status, and suggests the potential applicability of GSM as mycotoxin adsorbent in animal feed.</p>
</abstract>

This study investigated the effects of dietary inclusion of grape seed meal (GSM) on antioxidant markers in kidney of aflatoxin B1 fed pigs. Twenty-four cross-bred pigs (TOPIG-40) were randomly assigned to one of the four experimental diets: control (Control), aflatoxin B1 (diet contaminated with 320 μg AFB1/kg feed), grape seed meal (diet with 8% GSM) and AFB1+GSM (320 μg AFB1/kg feed + 8% GSM) for 30 days. Aflatoxin B1 induced oxidative damage and showed lower antioxidant status in kidney after 30 days. CAT and SOD activity measured in kidneys revealed significant differences when comparing the GSM+AFB1 group with the AFB1 group. Additionally, GSM diet alone did not affect CAT and SOD levels in kidneys of piglets compared with the control group, suggesting that they are maintained at physiological levels. We did not detect any effects of GSM on GPx and TAS. Including GSM into piglets’ diet significantly lowered lipid peroxidation induced by AFB1, while it did not affect it compared with the control group. The present study demonstrated the ability of GSM to alleviate the effects induced by the toxin evidenced by the improvement in the antioxidant status, and suggests the potential applicability of GSM as mycotoxin adsorbent in animal feed.

Response of antioxidant status in kidney of pigs exposed to aflatoxin B1 to dietary grape seed meal

Archiva Zootechnica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This study investigated the effects of dietary inclusion of grape seed meal (GSM) on antioxidant markers in kidney of aflatoxin B1 fed pigs. Twenty-four...

Response of antioxidant status in kidney of pigs exposed to aflatoxin B1 to dietary grape seed meal

Published Online: Jul 17, 2021

Page range: 17 - 30

DOI: https://doi.org/10.2478/azibna-2021-0002

Keywords
B1, piglets, inflammation, oxidative stress, grape seed meal

© 2021 Laurentiu Mihai Palade et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Response of antioxidant status in kidney of pigs exposed to aflatoxin B1 to dietary grape seed meal

Published Online: Jul 17, 2021

Page range: 17 - 30

DOI: https://doi.org/10.2478/azibna-2021-0002

KeywordsB1, piglets, inflammation, oxidative stress, grape seed meal

© 2021 Laurentiu Mihai Palade et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
B1, piglets, inflammation, oxidative stress, grape seed meal