<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The synthesis of five monocarbonyl analogues of curcumin is described. In vitro anti-malarial assay of the compounds was carried out and the effect of the substituents on the aryl ring has been described. The results show that all the five compounds exhibited some reasonable activity against the chloroquine-resistant plasmodium parasite. Molecular docking studies further confirmed the observed biological activity of the compounds.</p></abstract>

The synthesis of five monocarbonyl analogues of curcumin is described. In vitro anti-malarial assay of the compounds was carried out and the effect of the substituents on the aryl ring has been described. The results show that all the five compounds exhibited some reasonable activity against the chloroquine-resistant plasmodium parasite. Molecular docking studies further confirmed the observed biological activity of the compounds.

Synthesis, Antimalarial Activity, and Docking Studies of Monocarbonyl Analogues of Curcumin

Ovidius University Annals of Chemistry

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The synthesis of five monocarbonyl analogues of curcumin is described. In vitro anti-malarial assay of the compounds was carried out and the effect of the...

Synthesis, Antimalarial Activity, and Docking Studies of Monocarbonyl Analogues of Curcumin

Published Online: Oct 23, 2018

Page range: 92 - 96

Received: Dec 08, 2018

Accepted: Sep 20, 2018

DOI: https://doi.org/10.2478/auoc-2018-0013

Keywords
curcumin, monocarbonyl analogues, antimalarial activity, docking studies

© 2018 Amina S. Yusuf et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Synthesis, Antimalarial Activity, and Docking Studies of Monocarbonyl Analogues of Curcumin

Published Online: Oct 23, 2018

Page range: 92 - 96

Received: Dec 08, 2018

Accepted: Sep 20, 2018

DOI: https://doi.org/10.2478/auoc-2018-0013

Keywordscurcumin, monocarbonyl analogues, antimalarial activity, docking studies

© 2018 Amina S. Yusuf et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
curcumin, monocarbonyl analogues, antimalarial activity, docking studies