<abstract xmlns="http://www.w3.org/1999/xhtml"><p>This investigation was aimed to study the effect of Pinus halepensis aqueous bark extract and zinc to prevent indomethacin induced gastric ulcer in rats. Thirty female albino Wistar rats were divided into 6 groups of 5 animals each (n=5); Group 1: normal control, Group 2: ulcer rats received normal saline, Group 3: ulcer rats treated with P. halepensis, Group 4: ulcer rats were treated with zinc, Group 5: ulcer rats were treated with P. halepensis + zinc and Group 6 ulcer rats were treated with Ranitidine for 15 days. Stomach ulcer was induced by a single oral administration of indomethacin (30 mg/kg). Various biochimical, physiologic and histologic parameters were estimated. Obtained results show that the ulcer index, pH and total acidity level were significantly reduced (p&lt;0.05) and Pepsin activity was significantly increased (p&lt; 0.05) in ulcer induced rats pre-treated with extract of P. halepensis, zinc and ranitidine when compared with indomethacin treated rats. The MDA level was significantly decreased and GSH level was increased (p&lt; 0.05) in rats treated with plant extract and zinc. Histopathology of gastric mucosa confirmed the gastro-protection by plant and zinc treatment. The study reveals anti-ulcer and antioxidant properties were observed in bark aqueous extract of P. halepensis groups with a benefic effect of zinc to reduce oxidative stress and gastric ulcer induced in the rat.</p></abstract>

This investigation was aimed to study the effect of Pinus halepensis aqueous bark extract and zinc to prevent indomethacin induced gastric ulcer in rats. Thirty female albino Wistar rats were divided into 6 groups of 5 animals each (n=5); Group 1: normal control, Group 2: ulcer rats received normal saline, Group 3: ulcer rats treated with P. halepensis, Group 4: ulcer rats were treated with zinc, Group 5: ulcer rats were treated with P. halepensis + zinc and Group 6 ulcer rats were treated with Ranitidine for 15 days. Stomach ulcer was induced by a single oral administration of indomethacin (30 mg/kg). Various biochimical, physiologic and histologic parameters were estimated. Obtained results show that the ulcer index, pH and total acidity level were significantly reduced (p<0.05) and Pepsin activity was significantly increased (p< 0.05) in ulcer induced rats pre-treated with extract of P. halepensis, zinc and ranitidine when compared with indomethacin treated rats. The MDA level was significantly decreased and GSH level was increased (p< 0.05) in rats treated with plant extract and zinc. Histopathology of gastric mucosa confirmed the gastro-protection by plant and zinc treatment. The study reveals anti-ulcer and antioxidant properties were observed in bark aqueous extract of P. halepensis groups with a benefic effect of zinc to reduce oxidative stress and gastric ulcer induced in the rat.

Protective effect of zinc and Pine barks extract supplement against Indometacin-induced gastric ulcer in rats

Department of Cellular and Molecular Biology, Faculty of Natural and Life Sciences of

Laboratory of Biodiversity and application of biotechnology in the agricultural field, Faculty of natural and life sciences

Acta Scientifica Naturalis

This work is licensed under the Creative Commons Attribution 3.0 Public License.

This investigation was aimed to study the effect of Pinus halepensis aqueous bark extract and zinc to prevent indomethacin induced gastric ulcer in rats....

Protective effect of zinc and Pine barks extract supplement against Indometacin-induced gastric ulcer in rats

Published Online: Mar 18, 2021

Page range: 1 - 14

DOI: https://doi.org/10.2478/asn-2021-0002

Keywords
zinc, stomach ulcer, oxidative stress, Wistar rats

© 2021 Derouiche Samir et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 3.0 Public License.

Protective effect of zinc and Pine barks extract supplement against Indometacin-induced gastric ulcer in rats

Published Online: Mar 18, 2021

Page range: 1 - 14

DOI: https://doi.org/10.2478/asn-2021-0002

Keywordszinc, stomach ulcer, oxidative stress, Wistar rats

© 2021 Derouiche Samir et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 3.0 Public License.

Keywords
zinc, stomach ulcer, oxidative stress, Wistar rats