<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Sickle cell anaemia is a life-threatening genetic disease that causes damage to red blood cells by polymerisation of deoxygenated haemoglobin. It is highly prevalent in Africa especially in regions with high prevalence of malaria. Over the years, hydroxyurea had been the only promising drug used in the management of sickle cell anaemia; however, it has been found to be unaffordable and not readily available to the affected poor people in rural areas. Several challenges face drug development efforts in Africa yet there remains a significant need for the development and standardisation of newer, cheaper, and effective anti-sickling drugs that would be readily affordable and available to meet the needs of the African populace.</p>
</abstract>

Sickle cell anaemia is a life-threatening genetic disease that causes damage to red blood cells by polymerisation of deoxygenated haemoglobin. It is highly prevalent in Africa especially in regions with high prevalence of malaria. Over the years, hydroxyurea had been the only promising drug used in the management of sickle cell anaemia; however, it has been found to be unaffordable and not readily available to the affected poor people in rural areas. Several challenges face drug development efforts in Africa yet there remains a significant need for the development and standardisation of newer, cheaper, and effective anti-sickling drugs that would be readily affordable and available to meet the needs of the African populace.

Sickle cell Anaemia: The Need for Increased Drug Development in Africa

Annals of Public Health Issues

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Sickle cell Anaemia: The Need for Increased Drug Development in Africa"}

Sickle cell anaemia is a life-threatening genetic disease that causes damage to red blood cells by polymerisation of deoxygenated haemoglobin. It is highly...

Sickle cell Anaemia: The Need for Increased Drug Development in Africa

Published Online: Mar 07, 2022

Page range: 10 - 15

Received: Oct 01, 2021

Accepted: Jan 16, 2022

DOI: https://doi.org/10.2478/aphi-2022-0002

Keywords
Sickle, cell, disease, anaemia, drug, development, Africa

© 2022 Damilola Esther Olukorede et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Sickle cell Anaemia: The Need for Increased Drug Development in Africa

Published Online: Mar 07, 2022

Page range: 10 - 15

Received: Oct 01, 2021

Accepted: Jan 16, 2022

DOI: https://doi.org/10.2478/aphi-2022-0002

KeywordsSickle, cell, disease, anaemia, drug, development, Africa

© 2022 Damilola Esther Olukorede et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Sickle, cell, disease, anaemia, drug, development, Africa