<abstract xmlns="http://www.w3.org/1999/xhtml">

An attempt was made to evaluate histopathological changes in the gills, liver, and kidney tissues of the freshwater teleost <italic>Oreochromis niloticus</italic> as biomarkers of chlorpyrifos toxicity. An experiment was conducted in glass aquaria with <italic>O. niloticus</italic> exposed for 28 days to sub-lethal concentrations of chlorpyrifos of 0.0 µg L−1 (control), 10 µg L−1, and 20 µg L−1. Chlorpyrifos caused distortions of the primary gill lamellae structure, the curling of secondary lamellae, desquamation, and epithelial hyperplasia on secondary gill filaments. Hepatocyte vacuolation and nuclear membrane necrosis were found in the liver. Additionally, the shrinkage of the glomeruli, thickening of Bowman’s capsule, glomerular and tubular necrosis, intracytoplasmic vacuoles, and hyaline degeneration in the renal tubule were seen in the kidney of <italic>O. niloticus</italic> exposed to chlorpyrifos. No remarkable lesions were observed in the control group. The severity of lesions in the fish tissues was assessed using the standard semi-quantitative grading system. The degree of histopathological lesions in various fish tissues was found to increase with chlorpyrifos concentrations. Histopathological lesions appeared to be good biomarkers of chlorpyrifos toxicity.
</abstract>

An attempt was made to evaluate histopathological changes in the gills, liver, and kidney tissues of the freshwater teleost Oreochromis niloticus as biomarkers of chlorpyrifos toxicity. An experiment was conducted in glass aquaria with O. niloticus exposed for 28 days to sub-lethal concentrations of chlorpyrifos of 0.0 µg L−1 (control), 10 µg L−1, and 20 µg L−1. Chlorpyrifos caused distortions of the primary gill lamellae structure, the curling of secondary lamellae, desquamation, and epithelial hyperplasia on secondary gill filaments. Hepatocyte vacuolation and nuclear membrane necrosis were found in the liver. Additionally, the shrinkage of the glomeruli, thickening of Bowman’s capsule, glomerular and tubular necrosis, intracytoplasmic vacuoles, and hyaline degeneration in the renal tubule were seen in the kidney of O. niloticus exposed to chlorpyrifos. No remarkable lesions were observed in the control group. The severity of lesions in the fish tissues was assessed using the standard semi-quantitative grading system. The degree of histopathological lesions in various fish tissues was found to increase with chlorpyrifos concentrations. Histopathological lesions appeared to be good biomarkers of chlorpyrifos toxicity.

Effects of chlorpyrifos on histopathological biomarkers of the freshwater teleost <italic>Oreochromis niloticus</italic>

Fisheries & Aquatic Life

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effects of chlorpyrifos on histopathological biomarkers of the freshwater teleost 

An attempt was made to evaluate histopathological changes in the gills, liver, and kidney tissues of the freshwater teleost Oreochromis niloticus as biomarkers...

Effects of chlorpyrifos on histopathological biomarkers of the freshwater teleost Oreochromis niloticus

Published Online: Feb 08, 2024

Page range: 207 - 214

Received: Nov 13, 2022

Accepted: Dec 29, 2023

DOI: https://doi.org/10.2478/aopf-2023-0020

Keywords
histopathology, biomarkers, tissues, organophosphate, fish

© 2023 Rajib Majumder, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effects of chlorpyrifos on histopathological biomarkers of the freshwater teleost Oreochromis niloticus

Published Online: Feb 08, 2024

Page range: 207 - 214

Received: Nov 13, 2022

Accepted: Dec 29, 2023

DOI: https://doi.org/10.2478/aopf-2023-0020

Keywordshistopathology, biomarkers, tissues, organophosphate, fish

© 2023 Rajib Majumder, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
histopathology, biomarkers, tissues, organophosphate, fish