<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The aim of this study was to compare the postcapillary-sized venule (PCV) morphology of four young ALCA mice (35 days) and four colony-related aged mice (365 days) using the transmission electron microscope (TEM). Right and left mandibular first molar mesial roots with associated periodontal ligament (PDL) and bony socket, were used for TEM assessment. Five PCV profiles were selected at each 160µm interval, from the alveolar crest to the tooth apex. PCV profile dimensions were measured on standardised micrographs magnified x2900. Age affects were tested using multiple regression analysis. The number of PCV profiles in the tooth third of the PDL was higher in aged mice (<italic>p</italic> &lt; 0.01) and comprised predominantly apericytic vessels (<italic>p</italic> &lt; 0.001). The number of PCV profiles increased significantly (<italic>p</italic> &lt; 0.001) in aged mice in the PDL middle circumferential third halfway down the molar root. Age had no significant affect on PCV diameter. Aged PDL permeability studies are needed to investigate whether the changes in aged PCV profile number are associated with functional modification of the PDL microvasculature.</p>
</abstract>

The aim of this study was to compare the postcapillary-sized venule (PCV) morphology of four young ALCA mice (35 days) and four colony-related aged mice (365 days) using the transmission electron microscope (TEM). Right and left mandibular first molar mesial roots with associated periodontal ligament (PDL) and bony socket, were used for TEM assessment. Five PCV profiles were selected at each 160µm interval, from the alveolar crest to the tooth apex. PCV profile dimensions were measured on standardised micrographs magnified x2900. Age affects were tested using multiple regression analysis. The number of PCV profiles in the tooth third of the PDL was higher in aged mice (p < 0.01) and comprised predominantly apericytic vessels (p < 0.001). The number of PCV profiles increased significantly (p < 0.001) in aged mice in the PDL middle circumferential third halfway down the molar root. Age had no significant affect on PCV diameter. Aged PDL permeability studies are needed to investigate whether the changes in aged PCV profile number are associated with functional modification of the PDL microvasculature.

Ultrastructural changes in postcapillary-sized venule morphology in aged mouse periodontal ligament

Australasian Orthodontic Journal

This work is licensed under the Creative Commons Attribution 4.0 International License.

The aim of this study was to compare the postcapillary-sized venule (PCV) morphology of four young ALCA mice (35 days) and four colony-related aged mice (365...

Ultrastructural changes in postcapillary-sized venule morphology in aged mouse periodontal ligament

Published Online: Dec 15, 2023

Page range: 8 - 16

Received: Mar 01, 2000

Accepted: Jan 01, 2001

DOI: https://doi.org/10.2478/aoj-2001-0002

© 2001 J. Cameron et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.