<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Polyphenols are a group of compounds arousing enormous interest due to their multiple effects on both human and animal health and omnipresence in plants. A number of <italic>in vitro</italic> and animal model studies have shown that all polyphenols exhibit anti-inflammatory and antioxidant activities, and play a significant role against oxidative stress-related pathologies. They also exert gut promotory effects and prevent chronic degenerative diseases. However, less attention has been paid to the potential influence of polyphenols on bone properties and metabolism. It is well known that proper growth and functioning of the organism depend largely on bone growth and health. Therefore, understanding the action of substances (including polyphenols) that may improve the health and functioning of the skeletal system and bone metabolism is extremely important for the health of the present and future generations of both humans and farm animals. This review provides a comprehensive summary of literature related to causes of bone loss during ageing of the organism (in both humans and animals) and possible effects of dietary polyphenols preventing bone loss and diseases. In particular, the underlying cellular and molecular mechanisms that can modulate skeletal homeostasis and influence the bone modeling and remodeling processes are presented.</p></abstract>

Polyphenols are a group of compounds arousing enormous interest due to their multiple effects on both human and animal health and omnipresence in plants. A number of in vitro and animal model studies have shown that all polyphenols exhibit anti-inflammatory and antioxidant activities, and play a significant role against oxidative stress-related pathologies. They also exert gut promotory effects and prevent chronic degenerative diseases. However, less attention has been paid to the potential influence of polyphenols on bone properties and metabolism. It is well known that proper growth and functioning of the organism depend largely on bone growth and health. Therefore, understanding the action of substances (including polyphenols) that may improve the health and functioning of the skeletal system and bone metabolism is extremely important for the health of the present and future generations of both humans and farm animals. This review provides a comprehensive summary of literature related to causes of bone loss during ageing of the organism (in both humans and animals) and possible effects of dietary polyphenols preventing bone loss and diseases. In particular, the underlying cellular and molecular mechanisms that can modulate skeletal homeostasis and influence the bone modeling and remodeling processes are presented.

Role of Polyphenols in the Metabolism of the Skeletal System in Humans and Animals – A Review

Annals of Animal Science

This work is licensed under the Creative Commons Attribution 4.0 International License.

Polyphenols are a group of compounds arousing enormous interest due to their multiple effects on both human and animal health and omnipresence in plants. A...

Role of Polyphenols in the Metabolism of the Skeletal System in Humans and Animals – A Review

Published Online: Oct 28, 2021

Page range: 1275 - 1300

Received: Feb 12, 2021

Accepted: May 24, 2021

DOI: https://doi.org/10.2478/aoas-2021-0040

Keywords
polyphenols, bone metabolism, bone health

© 2021 Grzegorz Skiba et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Role of Polyphenols in the Metabolism of the Skeletal System in Humans and Animals – A Review

Published Online: Oct 28, 2021

Page range: 1275 - 1300

Received: Feb 12, 2021

Accepted: May 24, 2021

DOI: https://doi.org/10.2478/aoas-2021-0040

Keywordspolyphenols, bone metabolism, bone health

© 2021 Grzegorz Skiba et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
polyphenols, bone metabolism, bone health