1. bookVolume 19 (2019): Issue 2 (April 2019)
Journal Details
License
Format
Journal
eISSN
2300-8733
First Published
25 Nov 2011
Publication timeframe
4 times per year
Languages
English
access type Open Access

Redox Status, Hematological Parameters as Well Liver and Kidney Function Indicators in Blood of Chickens Receiving Gold Nanoparticles

Published Online: 02 May 2019
Volume & Issue: Volume 19 (2019) - Issue 2 (April 2019)
Page range: 453 - 468
Received: 11 Oct 2018
Accepted: 12 Dec 2018
Journal Details
License
Format
Journal
eISSN
2300-8733
First Published
25 Nov 2011
Publication timeframe
4 times per year
Languages
English
Abstract

The aim of the study was to assess the biocompatibility of gold nanoparticles (Au-NPs) for chickens by investigating their effect on their growth, hematological parameters, markers of oxidative stress, and indicators of liver and kidney function. The experiment was carried out on 54 chickens assigned to 3 experimental groups of 18 birds each. The control group did not receive gold nanoparticles. The birds in group Au-NPs2.0 received gold nanoparticles in a tube into a crop at a rate of 2.0 mg/kg body weight/day, while the birds in AuNPs5.0 group at a rate of 5.0 mg/kg body weight/day. The blood for analysis was collected after 7, 14, 21 and 28 days of Au-NPs application. The obtained results indicate that short-term (7–14 day) exposure to lower dose (2.0 mg/kg b.w./day) of AuNPs had no toxic impact on chickens, but the extension of the duration time caused toxicological effects evidenced by growth inhibition as well as induction of oxidative stress and liver injury. The higher dose of AuNPs (5.0 mg/kg b.w./day) exerted toxic effects already after 7–14 days of supplementation.

Keywords

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