1. bookVolume 14 (2014): Issue 1 (January 2014)
Journal Details
License
Format
Journal
eISSN
2300-8733
ISSN
1642-3402
First Published
25 Nov 2011
Publication timeframe
4 times per year
Languages
English
access type Open Access

Effect of Biolactin administered per os on survivability and body weight of piglets

Journal Details
License
Format
Journal
eISSN
2300-8733
ISSN
1642-3402
First Published
25 Nov 2011
Publication timeframe
4 times per year
Languages
English
Abstract

Prolactin (PRL) is a protein hormone synthesized in and secreted predominantly by lactotroph cells of the anterior pituitary gland. This hormone has been found to stimulate the immune system in animals. Because prolactin secreted in milk by the mother’s body is often insufficient, the administration of exogenous prolactin may significantly contribute to improving the health and growth of piglets. The aim of the study was to determine the dose of prolactin administered to newborn piglets to improve their survivability and growth rate. The study used Biolactin solution, produced on a semi-technical scale by FZNP Biochefa, which was administered per os to newborn piglets at a dose of 0.1, 0.5 and 1.0 mg PRL/kg body weight. NaCl physiological saline was used as a control. The number of piglets born alive, piglet body weight and mortality from birth to 21 and 28 days of age (weaning) were monitored. The study involved 98 litters (1197 piglets), which were divided into 3 experimental and 3 control groups. The experiment showed a positive effect of exogenous prolactin administered to newborn piglets on reducing their mortality and on increasing their birth to weaning growth rate. A dose of 0.5 mg PRL/kg body weight turned out to be optimal.

Keywords

Bole - Feysot C., Goffin V., Edery M., Binart N., Kelly P.A. (1998). Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL, receptor knockout mice. Endocrine Review, 19 (3): 225-284.Search in Google Scholar

Drożdż M., Ryszka F., Pardela M. (1998). Prolactin (PRL) -areview of current knowledge and new perspectives on clinical use. Med. Sci. Monit. 4 (1): 191-194.Search in Google Scholar

Dusza L., Sobczak J., Jana B., Murdza A., Bluj W. (1991). Application of Biolactin-2 (purified porcine prolactin) in stimulation of lactation in sows (in Polish). Med. Weter., 47 (9): 418-421.Search in Google Scholar

Gajda B., Szczęśniak - Fabiańczyk B., Grad I., Poniedziałek K., Ryszka F., Smorąg Z., Dolińska B., Leszczyńska L. (2011). Effect of “Biolactin” administered per os on viability and body weight of piglets. Acta Biochim. Pol., 58 (Suppl. No. 4), p. 147.Search in Google Scholar

Gajda B., Szczęśniak - Fabiańczyk B., Grad I., Poniedziałek K., Ryszka F., Smorąg Z., Dolińska B., Leszczyńska L. (2012). Effect of low prolactin dose administered per os on mortality and body weight of piglets. Reprod. Domestic. Anim., 47 (Suppl. 4), p. 574, abstr. 2855.Search in Google Scholar

Heber D., Bhasin S., Steiner B., Swerdloff R.S. (1984). The stimulatory and down-regulatory effects ofagonadotropin releasing hormone agonist in men. J. Clin. Endocrinol. Metab., 6: 1084-1088.Search in Google Scholar

Meller W.H., Grambsch P.L., Bingham C. (2001). Hypothalamic pituitary gonadal axis dysregulation in depressed women. Psychoneuroendocrinology, 26: 253-259.Search in Google Scholar

Michalik J., Bartoszewicz Z. (2002). Prolactin -amultifunctional, pituitary, peptide hormone. (in Polish). Postępy Biochemii, 48 (4): 296-305.Search in Google Scholar

Neill J.D., Nagy G.M., (1994). Prolactin secretion and its control. In: E. Knobil and J.D. Neill (eds). The Physiology of Reproduction. Second edition, Raven Press, New York, USA, pp. 1833-1860.Search in Google Scholar

Przała J., Gajęcki M., Przała F., Ryszka F. (1992). Prophylactic application of Biolactin-2 preparation in replacement gilts and the MMAsyndrome (in Polish). Med. Weter., 48 (1): 31-33.Search in Google Scholar

Smorąg Z., Ryszka F., Dolińska B., Szczęśniak - Fabiańczyk B., Leszczyń -ska L., Koska M., Kowalski W. (2008). Effect of prolactin administered per os on body gain and health of piglets. Acta Bioch. Pol., 55 (Suppl. No. 4), p. 133.Search in Google Scholar

Szczęśniak - Fabiańczyk B., Dolińska B., Ryszka F., Smorąg Z. (2002). Efficiency of Biolactin administered to primiparous and multiparous sows. Ann. Anim. Sci., 2 (Suppl. No. 2): 173-176. Search in Google Scholar

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