<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>This paper proposed an approach for the identification of mutation mechanisms of breast cancer in women in four member countries of the Middle East Cancer Consortium i.e. Egypt, Jordan, Cyprus and Israel (Arabs and Jews). We set up multistage models including both gene mutation and the clonal expansion of intermediate cells. We fit the data-set related to the incidence of female breast cancer in the four member countries. Our simulation results show that the maximum number of driver mutations of breast epithelium stem cells of Egyptian women is 13, whereas there are 14 driver mutations in the genome of stem cells of female patients in Jordan, Cyprus and Israel (Arabs and Jews). In addition, the 3, 10, 5, 5 and 4 stage models are the optimal ones for the tumorigenesis of females in Egypt, Jordan, Cyprus, Israel (Arabs) and Israel (Jews), respectively. The genomic instability is caused by first three driver mutations.</p>
</abstract>

This paper proposed an approach for the identification of mutation mechanisms of breast cancer in women in four member countries of the Middle East Cancer Consortium i.e. Egypt, Jordan, Cyprus and Israel (Arabs and Jews). We set up multistage models including both gene mutation and the clonal expansion of intermediate cells. We fit the data-set related to the incidence of female breast cancer in the four member countries. Our simulation results show that the maximum number of driver mutations of breast epithelium stem cells of Egyptian women is 13, whereas there are 14 driver mutations in the genome of stem cells of female patients in Jordan, Cyprus and Israel (Arabs and Jews). In addition, the 3, 10, 5, 5 and 4 stage models are the optimal ones for the tumorigenesis of females in Egypt, Jordan, Cyprus, Israel (Arabs) and Israel (Jews), respectively. The genomic instability is caused by first three driver mutations.

Modeling the pathway of breast cancer in the Middle East

Faculty of Science, Mathematics Department

Applied Mathematics and Nonlinear Sciences

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"Modeling the pathway of breast cancer in the Middle East"}

This paper proposed an approach for the identification of mutation mechanisms of breast cancer in women in four member countries of the Middle East Cancer...

Modeling the pathway of breast cancer in the Middle East

Published Online: Nov 19, 2021

Page range: 147 - 166

Received: Nov 20, 2019

Accepted: Apr 11, 2021

DOI: https://doi.org/10.2478/amns.2021.2.00050

Keywords
breast cancer, multi-stage model, incidence rate, chi square test

© 2023 Asmaa Amer et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Modeling the pathway of breast cancer in the Middle East

Published Online: Nov 19, 2021

Page range: 147 - 166

Received: Nov 20, 2019

Accepted: Apr 11, 2021

DOI: https://doi.org/10.2478/amns.2021.2.00050

Keywordsbreast cancer, multi-stage model, incidence rate, chi square test

© 2023 Asmaa Amer et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
breast cancer, multi-stage model, incidence rate, chi square test