<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Salmonella is a Gram-negative, non-spore-forming, motile, facultative anaerobic rod. The most studied species are <italic>Salmonella typhi</italic> and <italic>paratyphi</italic> (causing typhoid fever) and non-typhi <italic>Salmonella</italic> species (which can cause different clinical syndromes - gastroenteritis, disseminated infections, etc.). A 61-year-old male patient with multiple comorbidities (including myelofibrosis) presented to the Pulmonology outpatient department, Clinical County Hospital of Târgu Mureș, with a mucopurulent nocturnal cough. Paraclinical examinations showed the presence of a pleural empyema, which was evacuated in local anesthesia. The pleural fluid was sent to the Microbiology Department for bacteriological testing, where a fluoroquinolone-resistant strain of <italic>Salmonella</italic> spp. was detected. The patient received antibiotic treatment according to the antibiotic susceptibility testing. Due to the persistence of the symptoms, the patient returned two weeks later, when another puncture was performed. <italic>Salmonella</italic> was isolated again, but the strain showed a higher resistance to antibiotics. The two strains were compared using molecular methods of diagnosis (Enterobacterial Repetitive Intergenic Consensus Polymerase Chain Reaction - ERIC-PCR), the results showing a similarity of 92%. The occurrence of an extra amplicon band in ERIC-PCR suggests an important change in the bacterial genetic material, potentially related to acquisition of antibiotic resistance factors.</p>
</abstract>

Salmonella is a Gram-negative, non-spore-forming, motile, facultative anaerobic rod. The most studied species are Salmonella typhi and paratyphi (causing typhoid fever) and non-typhi Salmonella species (which can cause different clinical syndromes - gastroenteritis, disseminated infections, etc.). A 61-year-old male patient with multiple comorbidities (including myelofibrosis) presented to the Pulmonology outpatient department, Clinical County Hospital of Târgu Mureș, with a mucopurulent nocturnal cough. Paraclinical examinations showed the presence of a pleural empyema, which was evacuated in local anesthesia. The pleural fluid was sent to the Microbiology Department for bacteriological testing, where a fluoroquinolone-resistant strain of Salmonella spp. was detected. The patient received antibiotic treatment according to the antibiotic susceptibility testing. Due to the persistence of the symptoms, the patient returned two weeks later, when another puncture was performed. Salmonella was isolated again, but the strain showed a higher resistance to antibiotics. The two strains were compared using molecular methods of diagnosis (Enterobacterial Repetitive Intergenic Consensus Polymerase Chain Reaction - ERIC-PCR), the results showing a similarity of 92%. The occurrence of an extra amplicon band in ERIC-PCR suggests an important change in the bacterial genetic material, potentially related to acquisition of antibiotic resistance factors.

Beyond the gut - Atypical presentation of <italic>Salmonella</italic> spp. infection

George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution 4.0 International License.

Beyond the gut - Atypical presentation of  spp. infection

Salmonella is a Gram-negative, non-spore-forming, motile, facultative anaerobic rod. The most studied species are Salmonella typhi and paratyphi (causing...

Beyond the gut - Atypical presentation of Salmonella spp. infection

Published Online: Jul 03, 2024

Page range: 87 - 94

Received: May 22, 2024

Accepted: May 28, 2024

DOI: https://doi.org/10.2478/amma-2024-0014

Keywords
pleural empyema, extraintestinal salmonellosis

© 2024 Anca Cighir et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Beyond the gut - Atypical presentation of Salmonella spp. infection

Published Online: Jul 03, 2024

Page range: 87 - 94

Received: May 22, 2024

Accepted: May 28, 2024

DOI: https://doi.org/10.2478/amma-2024-0014

Keywordspleural empyema, extraintestinal salmonellosis

© 2024 Anca Cighir et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
pleural empyema, extraintestinal salmonellosis