<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Introduction</bold>: Bones, lungs, brain and liver are the most common metastatic sites of breast carcinoma, although invasive lobular carcinoma can give metastases to less common sites, such as the gastrointestinal tract and the female genital tract.
<bold>Case presentation</bold>: We present the case of a 57-year-old female with colic abdominal pain that was sent to surgery for cholecystectomy. Histopathology revealed a poorly cohesive individual or in single file neoplastic cells infiltrating all layers of the gallbladder. Immunohistochemistry revealed these cells to be CK 116, CK7, GCDFP-15, ER and PR positive, and CK20, HER-2, S-100 and E-cadherin negative. PET/CT showed numerous lytic bone lesions, but ultrasound, mammography, MRI and PET/CT revealed no breast mass.
<bold>Conclusion</bold>: Although rare and poorly understood, metastases of invasive lobular carcinoma to gallbladder do exist in a minor percentage of patients, presenting usually as exacerbated cholecystitis. The problem are silent cases and patients with no history of breast carcinoma. This case is unique in that even after the diagnosis of metastatic lobular breast carcinoma to the gallbladder, the primary tumour of the breast was not detected.
</abstract>

Introduction: Bones, lungs, brain and liver are the most common metastatic sites of breast carcinoma, although invasive lobular carcinoma can give metastases to less common sites, such as the gastrointestinal tract and the female genital tract.
Case presentation: We present the case of a 57-year-old female with colic abdominal pain that was sent to surgery for cholecystectomy. Histopathology revealed a poorly cohesive individual or in single file neoplastic cells infiltrating all layers of the gallbladder. Immunohistochemistry revealed these cells to be CK 116, CK7, GCDFP-15, ER and PR positive, and CK20, HER-2, S-100 and E-cadherin negative. PET/CT showed numerous lytic bone lesions, but ultrasound, mammography, MRI and PET/CT revealed no breast mass.
Conclusion: Although rare and poorly understood, metastases of invasive lobular carcinoma to gallbladder do exist in a minor percentage of patients, presenting usually as exacerbated cholecystitis. The problem are silent cases and patients with no history of breast carcinoma. This case is unique in that even after the diagnosis of metastatic lobular breast carcinoma to the gallbladder, the primary tumour of the breast was not detected.

Gallbladder metastasis from occult lobular breast carcinoma: A case report

Department of Pathology, Faculty of Medicine

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"Gallbladder metastasis from occult lobular breast carcinoma: A case report"}

Introduction: Bones, lungs, brain and liver are the most common metastatic sites of breast carcinoma, although invasive lobular carcinoma can give metastases...

Gallbladder metastasis from occult lobular breast carcinoma: A case report

Published Online: Dec 28, 2023

Page range: 295 - 298

Received: Jun 14, 2023

Accepted: Oct 03, 2023

DOI: https://doi.org/10.2478/amma-2023-0041

Keywords
lobular carcinoma, breast, metastasis, gallbladder

© 2023 Mirsad Dorić et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Gallbladder metastasis from occult lobular breast carcinoma: A case report

Published Online: Dec 28, 2023

Page range: 295 - 298

Received: Jun 14, 2023

Accepted: Oct 03, 2023

DOI: https://doi.org/10.2478/amma-2023-0041

Keywordslobular carcinoma, breast, metastasis, gallbladder

© 2023 Mirsad Dorić et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
lobular carcinoma, breast, metastasis, gallbladder