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WHO. Epilepsy. 2022; https://www.who.int/en/news-room/fact-sheets/detail/epilepsy. Accessed August 1, 2022.Search in Google Scholar
Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. Jun 2010;51(6):1069-1077 DOI: 10.1111/j.1528-1167.2009.02397.x.Search in Google Scholar
Wiebe S, Jette N. Pharmacoresistance and the role of surgery in difficult to treat epilepsy. Nat Rev Neurol. Dec 2012;8(12):669-677 DOI: 10.1038/nrneurol.2012.181.Search in Google Scholar
Spencer D, Burchiel K. Selective amygdalohippocampectomy. Epilepsy Res Treat. 2012;2012:382095 DOI: 10.1155/2012/382095.Search in Google Scholar
Kim DW, Kim HK, Lee SK, Chu K, Chung CK. Extent of neocortical resection and surgical outcome of epilepsy: intracranial EEG analysis. Epilepsia. Jun 2010;51(6):1010-1017 DOI: 10.1111/j.1528-1167.2010.02567.x.Search in Google Scholar
Englot DJ, Raygor KP, Molinaro AM, et al. Factors associated with failed focal neocortical epilepsy surgery. Neurosurgery. Dec 2014;75(6):648-645;discussion 655; quiz 656 DOI: 10.1227/NEU.0000000000000530.Search in Google Scholar
Eastin TM, Lopez-Gonzalez MA. Stimulation and Neuromodulation in the Treatment of Epilepsy. Brain Sci. Dec 21 2017;8(1) DOI: 10.3390/brainsci8010002.Search in Google Scholar
Tellez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain. May 2005;128(Pt 5):1188-1198 DOI: 10.1093/brain/awh449.Search in Google Scholar
Bigelow MD, Kouzani AZ. Neural stimulation systems for the control of refractory epilepsy: a review. J Neuroeng Rehabil. Oct 29 2019;16(1):126 DOI: 10.1186/s12984-019-0605-x.Search in Google Scholar
Ma BB, Rao VR. Responsive neurostimulation: Candidates and considerations. Epilepsy Behav. Nov 2018;88:388-395 DOI: 10.1016/j.yebeh.2018.09.032.Search in Google Scholar
Boon P, De Cock E, Mertens A, Trinka E. Neurostimulation for drug-resistant epilepsy: a systematic review of clinical evidence for efficacy, safety, contraindications and predictors for response. Curr Opin Neurol. Apr 2018;31(2):198-210 DOI: 10.1097/WCO.0000000000000534.Search in Google Scholar
Kim D, Kim T, Hwang Y, et al. Prediction of the Responsiveness to Vagus-Nerve Stimulation in Patients with Drug-Resistant Epilepsy via Directed-Transfer-Function Analysis of Their Perioperative Scalp EEGs. Journal of Clinical Medicine. 2022;11(13):3695 DOI: 10.3390/jcm11133695.Search in Google Scholar
Ryvlin P, Jehi LE. Neuromodulation for Refractory Epilepsy. Epilepsy Curr. Jan-Feb 2022;22(1):11-17 DOI: 10.1177/15357597211065587.Search in Google Scholar
Lanska DJ. J.L. Corning and vagal nerve stimulation for seizures in the 1880s. Neurology. Feb 12 2002;58(3):452-459 DOI: 10.1212/wnl.58.3.452.Search in Google Scholar
Yang J, Phi JH. The Present and Future of Vagus Nerve Stimulation. J Korean Neurosurg Soc. May 2019;62(3):344-352 DOI: 10.3340/jkns.2019.0037.Search in Google Scholar
Afra P, Adamolekun B, Aydemir S, Watson GDR. Evolution of the Vagus Nerve Stimulation (VNS) Therapy System Technology for Drug-Resistant Epilepsy. Front Med Technol. 2021;3:696543 DOI: 10.3389/fmedt.2021.696543.Search in Google Scholar
LivaNova USA I. BRIEF SUMMARY OF SAFETY INFORMATION FOR THE VNS THERAPY®SYSTEM [EPILEPSY INDICATION]. 2021; https://www.livanova.com/epilepsy-vnstherapy/en-us/hcp/safety-information. Accessed August 15, 2022.Search in Google Scholar
Suller Marti A, Mirsattari SM, Steven DA, et al. Experience on the use of Vagus Nerve Stimulation during pregnancy. Epilepsy Res. Oct 2019;156:106186 DOI: 10.1016/j.eplepsyres.2019.106186.Search in Google Scholar
Fetzer S, Dibue M, Nagel AM, Trollmann R. A systematic review of magnetic resonance imaging in patients with an implanted vagus nerve stimulation system. Neuroradiology. Sep 2021;63(9):1407-1417 DOI: 10.1007/s00234-021-02705-y.Search in Google Scholar
Thompson SL, O’Leary GH, Austelle CW, et al. A Review of Parameter Settings for Invasive and Non-invasive Vagus Nerve Stimulation (VNS) Applied in Neurological and Psychiatric Disorders. Front Neurosci. 2021;15:709436 DOI: 10.3389/fnins.2021.709436.Search in Google Scholar
Cyberonics I. VNS Therapy System manuals. 2021; https://dynamic.cyberonics.com/manuals/index_iframe.asp. Accessed August 17, 2022.Search in Google Scholar
Schulze-Bonhage A. Brain stimulation as a neuromodulatory epilepsy therapy. Seizure. Jan 2017;44:169-175 DOI: 10.1016/j.seizure.2016.10.026.Search in Google Scholar
Fisher RS, Afra P, Macken M, et al. Automatic Vagus Nerve Stimulation Triggered by Ictal Tachycardia: Clinical Outcomes and Device Performance--The U.S. E-37 Trial. Neuromodulation. Feb 2016;19(2):188-195 DOI: 10.1111/ner.12376.Search in Google Scholar
Toffa DH, Touma L, El Meskine T, Bouthillier A, Nguyen DK. Learnings from 30 years of reported efficacy and safety of vagus nerve stimulation (VNS) for epilepsy treatment: A critical review. Seizure. Dec 2020;83:104-123 DOI: 10.1016/j.seizure.2020.09.027.Search in Google Scholar
Kim JS, Kim DY, Jo HJ, et al. Effect of Long-Term Treatment with Vagus Nerve Stimulation on Mood and Quality of Life in Korean Patients with Drug-Resistant Epilepsy. J Clin Neurol. Jul 2021;17(3):385-392 DOI: 10.3988/jcn.2021.17.3.385.Search in Google Scholar
Helmers SL, Griesemer DA, Dean JC, et al. Observations on the use of vagus nerve stimulation earlier in the course of pharmacoresistant epilepsy: patients with seizures for six years or less. Neurologist. May 2003;9(3):160-164 DOI: 10.1097/00127893-200305000-00004.Search in Google Scholar
Mamounas LA, Altar CA, Blue ME, Kaplan DR, Tessarollo L, Lyons WE. BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. J Neurosci. Jan 15 2000;20(2):771-782 DOI: 10.1523/JNEUROSCI.20-02-00771.2000.Search in Google Scholar
Zagon A, Kemeny AA. Slow hyperpolarization in cortical neurons: a possible mechanism behind vagus nerve simulation therapy for refractory epilepsy? Epilepsia. Nov 2000;41(11):1382-1389 DOI: 10.1111/j.1528-1157.2000.tb00113.x.Search in Google Scholar
Raedt R, Clinckers R, Mollet L, et al. Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model. J Neurochem. May 2011;117(3):461-469 DOI: 10.1111/j.1471-4159.2011.07214.x.Search in Google Scholar
Navidhamidi M, Mehranfard N. Vagal nerve stimulation for refractory epilepsy: A brief review. Neuropsychiatry. 01/01 2016;6:149-160 DOI: 10.4172/Neuropsychiatry.1000134.Search in Google Scholar
Broncel A, Bocian R, Klos-Wojtczak P, Kulbat-Warycha K, Konopacki J. Vagal nerve stimulation as a promising tool in the improvement of cognitive disorders. Brain Res Bull. Feb 2020;155:37-47 DOI: 10.1016/j.brainresbull.2019.11.011.Search in Google Scholar
Lomarev M, Denslow S, Nahas Z, Chae JH, George MS, Bohning DE. Vagus nerve stimulation (VNS) synchronized BOLD fMRI suggests that VNS in depressed adults has frequency/dose dependent effects. J Psychiatr Res. Jul-Aug 2002;36(4):219-227 DOI: 10.1016/s0022-3956(02)00013-4.Search in Google Scholar
Henry TR, Bakay RA, Pennell PB, Epstein CM, Votaw JR. Brain blood-flow alterations induced by therapeutic vagus nerve stimulation in partial epilepsy: II. prolonged effects at high and low levels of stimulation. Epilepsia. Sep 2004;45(9):1064-1070 DOI: 10.1111/j.0013-9580.2004.03104.x.Search in Google Scholar
Kunii N, Koizumi T, Kawai K, Shimada S, Saito N. Vagus Nerve Stimulation Amplifies Task-Induced Cerebral Blood Flow Increase. Front Hum Neurosci. 2021;15:726087 DOI: 10.3389/fnhum.2021.726087.Search in Google Scholar
Zhu J, Xu C, Zhang X, et al. Grey and white matter microstructure changes in epilepsy patients with vagus nerve stimulators. Clin Neurol Neurosurg. Oct 2021;209:106918 DOI: 10.1016/j.clineuro.2021.106918.Search in Google Scholar
Lv H, Zhao YH, Chen JG, Wang DY, Chen H. Vagus Nerve Stimulation for Depression: A Systematic Review. Front Psychol. 2019;10:64 DOI: 10.3389/fpsyg.2019.00064.Search in Google Scholar
Eggleston KS, Olin BD, Fisher RS. Ictal tachycardia: the head-heart connection. Seizure. Aug 2014;23(7):496-505 DOI: 10.1016/j.seizure.2014.02.012.Search in Google Scholar
Tatum WOt, Helmers SL. Vagus nerve stimulation and magnet use: optimizing benefits. Epilepsy Behav. Jul 2009;15(3):299-302 DOI: 10.1016/j.yebeh.2009.04.002.Search in Google Scholar
Tzadok M, Harush A, Nissenkorn A, Zauberman Y, Feldman Z, Ben-Zeev B. Clinical outcomes of closed-loop vagal nerve stimulation in patients with refractory epilepsy. Seizure. Oct 2019;71:140-144 DOI: 10.1016/j.seizure.2019.07.006.Search in Google Scholar
Winston GM, Guadix S, Lavieri MT, et al. Closed-loop vagal nerve stimulation for intractable epilepsy: A single-center experience. Seizure. May 2021;88:95-101 DOI: 10.1016/j.seizure.2021.03.030.Search in Google Scholar
Polkey CE, Nashef L, Queally C, Selway R, Valentin A. Long-term outcome of vagus nerve stimulation for drug-resistant epilepsy using continuous assessment, with a note on mortality. Seizure. 2022/03/01/2022;96:74-78 DOI: https://doi.org/10.1016/j.seizure.2022.01.017.Search in Google Scholar
Fahoum F, Boffini M, Kann L, et al. VNS parameters for clinical response in Epilepsy. Brain Stimul. May-Jun 2022;15(3):814-821 DOI: 10.1016/j.brs.2022.05.016.Search in Google Scholar
Panebianco M, Rigby A, Weston J, Marson AG. Vagus nerve stimulation for partial seizures. Cochrane Database Syst Rev. Apr 3 2015(4):CD002896 DOI: 10.1002/14651858.CD002896.pub2.Search in Google Scholar
Elliott RE, Rodgers SD, Bassani L, et al. Vagus nerve stimulation for children with treatment-resistant epilepsy: a consecutive series of 141 cases. J Neurosurg Pediatr. May 2011;7(5):491-500 DOI: 10.3171/2011.2.PEDS10505.Search in Google Scholar
Englot DJ, Chang EF, Auguste KI. Efficacy of vagus nerve stimulation for epilepsy by patient age, epilepsy duration, and seizure type. Neurosurg Clin N Am. Oct 2011;22(4):443-448, v DOI: 10.1016/j.nec.2011.07.002.Search in Google Scholar
Ching J, Khan S, White P, et al. Long-term effectiveness and tolerability of vagal nerve stimulation in adults with intractable epilepsy: a retrospective analysis of 100 patients. Br J Neurosurg. Apr 2013;27(2):228-234 DOI: 10.3109/02688697.2012.732716.Search in Google Scholar
Arcand J, Waterhouse K, Hernandez-Ronquillo L, Vitali A, Tellez-Zenteno JF. Efficacy of Vagal Nerve Stimulation for Drug-Resistant Epilepsy: Is it the Stimulation or Medication? Can J Neurol Sci. Sep 2017;44(5):532-537 DOI: 10.1017/cjn.2017.46.Search in Google Scholar
Kawai K, Tanaka T, Baba H, et al. Outcome of vagus nerve stimulation for drug-resistant epilepsy: the first three years of a prospective Japanese registry. Epileptic Disord. Sep 1 2017;19(3):327-338 DOI: 10.1684/epd.2017.0929.Search in Google Scholar
Flesler S, Reyes G, Fortini S, et al. [Vagus nerve stimulation: treatment of 158 pediatric patients with a long-term follow-up]. Rev Neurol. Jun 1 2017;64(11):496-501.Search in Google Scholar
Boluk C, Ozkara C, Isler C, Uzan M. Vagus Nerve Stimulation in Intractable Epilepsy. Turk Neurosurg. 2022;32(1):97-102 DOI: 10.5137/1019-5149.JTN.33775-21.2.Search in Google Scholar
Kostov KH, Kostov H, Larsson PG, et al. Norwegian population-based study of long-term effects, safety, and predictors of response of vagus nerve stimulation treatment in drug-resistant epilepsy: The NORPulse study. Epilepsia. Feb 2022;63(2):414-425 DOI: 10.1111/epi.17152.Search in Google Scholar
