<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The term amyloidosis refers to a wide range of diseases in which amorphous, extracellular, eosinophilic proteinaceous deposits form at various locations. In this article, we describe a case of amyloidosis with multiple myeloma in which the oral symptoms of the disease served as the main diagnostic clues. A male patient in his early 60s who had multiple tongue swellings presented to our department. Following an incisional biopsy, histological analysis revealed the presence of eosinophilic, amorphous hyaline-like material that was positive for Congo red staining and was indicative of amyloidosis. The presence of abnormal plasma cells in the patient’s bone marrow aspiration after the biopsy was done was suggestive of multiple myeloma. The patient is currently undergoing the CyBorD (Cyclophosphamide, Bortezomib, and Dexamethasone) treatment for multiple myeloma that has just been diagnosed. We offer this instance to demonstrate that, although uncommon, amyloidosis can initially only manifest as numerous swellings on the tongue.</p>
</abstract>

The term amyloidosis refers to a wide range of diseases in which amorphous, extracellular, eosinophilic proteinaceous deposits form at various locations. In this article, we describe a case of amyloidosis with multiple myeloma in which the oral symptoms of the disease served as the main diagnostic clues. A male patient in his early 60s who had multiple tongue swellings presented to our department. Following an incisional biopsy, histological analysis revealed the presence of eosinophilic, amorphous hyaline-like material that was positive for Congo red staining and was indicative of amyloidosis. The presence of abnormal plasma cells in the patient’s bone marrow aspiration after the biopsy was done was suggestive of multiple myeloma. The patient is currently undergoing the CyBorD (Cyclophosphamide, Bortezomib, and Dexamethasone) treatment for multiple myeloma that has just been diagnosed. We offer this instance to demonstrate that, although uncommon, amyloidosis can initially only manifest as numerous swellings on the tongue.

Oral manifestations of amyloidosis in a multiple myeloma patient: A case report

Department of Oral Medicine and Radiology

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"Oral manifestations of amyloidosis in a multiple myeloma patient: A case report"}

The term amyloidosis refers to a wide range of diseases in which amorphous, extracellular, eosinophilic proteinaceous deposits form at various locations. In...

Oral manifestations of amyloidosis in a multiple myeloma patient: A case report

Published Online: Jun 30, 2023

Page range: 131 - 134

Received: Mar 13, 2023

Accepted: Apr 29, 2023

DOI: https://doi.org/10.2478/amma-2023-0019

Keywords
amyloidosis, multiple myeloma, tongue, amyloid

© 2023 Jayachandran Sadaksharam et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Oral manifestations of amyloidosis in a multiple myeloma patient: A case report

Published Online: Jun 30, 2023

Page range: 131 - 134

Received: Mar 13, 2023

Accepted: Apr 29, 2023

DOI: https://doi.org/10.2478/amma-2023-0019

Keywordsamyloidosis, multiple myeloma, tongue, amyloid

© 2023 Jayachandran Sadaksharam et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
amyloidosis, multiple myeloma, tongue, amyloid