<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Objective</bold>: Our study aimed to validate the neutrophil-to-lymphocyte ratio (NLR) as a marker for aortic arch calcification in hypertensive patients with less advanced chronic kidney disease (CKD).<bold>Methods</bold>: A number of forty-four hypertensive patients with chronic kidney disease (categories G3a and G3b – 2012 KDIGO nomenclature) were included in the study. Considering the presence of aortic arch calcification (AAC) on chest X-ray, the study population was divided into two groups: 27 patients AAC present and seventeen without aortic arch calcification. Laboratory data were collected for each patient and NLR was computed. Comorbidities were also recorded: stable coronary artery disease, lower extremity arterial disease and hypertensive heart disease.<bold>Results</bold>: A positive correlation between neutrophil-to-lymphocyte ratio and aortic arch calcification in hypertensive CKD patients was identified. Furthermore, advanced age, increased alkaline phosphatase and increased erythrocyte sedimentation rate had a positive association with aortic arch calcification. We found no statistical correlation between neutrophil-to-lymphocyte ratio and other laboratory features in both groups of patients.<bold>Conclusions</bold>: Neutrophil-to-lymphocyte ratio may be viewed as a potential risk factor for vascular calcification in patients with moderate chronic kidney disease; nevertheless, future extensive studies are necessary. In the management of hypertensive patients, general medicine might particularly benefit of this simple, readily available inflammatory marker.</abstract>

Objective: Our study aimed to validate the neutrophil-to-lymphocyte ratio (NLR) as a marker for aortic arch calcification in hypertensive patients with less advanced chronic kidney disease (CKD).Methods: A number of forty-four hypertensive patients with chronic kidney disease (categories G3a and G3b – 2012 KDIGO nomenclature) were included in the study. Considering the presence of aortic arch calcification (AAC) on chest X-ray, the study population was divided into two groups: 27 patients AAC present and seventeen without aortic arch calcification. Laboratory data were collected for each patient and NLR was computed. Comorbidities were also recorded: stable coronary artery disease, lower extremity arterial disease and hypertensive heart disease.Results: A positive correlation between neutrophil-to-lymphocyte ratio and aortic arch calcification in hypertensive CKD patients was identified. Furthermore, advanced age, increased alkaline phosphatase and increased erythrocyte sedimentation rate had a positive association with aortic arch calcification. We found no statistical correlation between neutrophil-to-lymphocyte ratio and other laboratory features in both groups of patients.Conclusions: Neutrophil-to-lymphocyte ratio may be viewed as a potential risk factor for vascular calcification in patients with moderate chronic kidney disease; nevertheless, future extensive studies are necessary. In the management of hypertensive patients, general medicine might particularly benefit of this simple, readily available inflammatory marker.

Markers of Atherosclerosis in Hypertensive Patients with Less Advanced Chronic Kidney Disease

University of Medicine, Pharmacy, Science and Technology of Targu Mures

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Objective: Our study aimed to validate the neutrophil-to-lymphocyte ratio (NLR) as a marker for aortic arch calcification in hypertensive patients with less...

Markers of Atherosclerosis in Hypertensive Patients with Less Advanced Chronic Kidney Disease

Published Online: Sep 26, 2019

Page range: 91 - 96

Received: Aug 03, 2019

Accepted: Aug 22, 2019

DOI: https://doi.org/10.2478/amma-2019-0022

Keywords
neutrophil-to-lymphocyte ratio, atherosclerosis, systemic hypertension, chronic kidney disease, aortic arch calcification

© 2019 Claudia Floriana Suciu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Markers of Atherosclerosis in Hypertensive Patients with Less Advanced Chronic Kidney Disease

Published Online: Sep 26, 2019

Page range: 91 - 96

Received: Aug 03, 2019

Accepted: Aug 22, 2019

DOI: https://doi.org/10.2478/amma-2019-0022

Keywordsneutrophil-to-lymphocyte ratio, atherosclerosis, systemic hypertension, chronic kidney disease, aortic arch calcification

© 2019 Claudia Floriana Suciu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
neutrophil-to-lymphocyte ratio, atherosclerosis, systemic hypertension, chronic kidney disease, aortic arch calcification