<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Heart failure still represents a real challenge both in everyday practice and research, due to the complex issues related to its pathogenesis and management. Humoral biomarkers have emerged in the last decades as useful tools in the diagnosis, risk stratification and guiding the treatment of heart failure. These molecules are related to different pathological and adaptive processes, like myocardial injury, neurohormonal activation and cardiac remodeling, their most widespread representatives being the natriuretic peptides (e.g. NT-proBNP). The role of altered gene expression and transcription as the basis of myocardial structural and functional changes in heart failure is largely recognized. MicroRNAs (miRNAs) are non-coding RNAs which have a major role in post-transcriptional gene expression by interfering with messenger RNA molecules. Our short review summarizes the molecular biology of miRNAs and their possible role as biomarkers in the diagnosis and prognosis of heart failure. Furthermore, the therapeutical perspectives conferred by these molecules are also presented.</p></abstract>

Heart failure still represents a real challenge both in everyday practice and research, due to the complex issues related to its pathogenesis and management. Humoral biomarkers have emerged in the last decades as useful tools in the diagnosis, risk stratification and guiding the treatment of heart failure. These molecules are related to different pathological and adaptive processes, like myocardial injury, neurohormonal activation and cardiac remodeling, their most widespread representatives being the natriuretic peptides (e.g. NT-proBNP). The role of altered gene expression and transcription as the basis of myocardial structural and functional changes in heart failure is largely recognized. MicroRNAs (miRNAs) are non-coding RNAs which have a major role in post-transcriptional gene expression by interfering with messenger RNA molecules. Our short review summarizes the molecular biology of miRNAs and their possible role as biomarkers in the diagnosis and prognosis of heart failure. Furthermore, the therapeutical perspectives conferred by these molecules are also presented.

MicroRNAs as Biomarkers and Therapeutic Targets in Heart Failure

University of Medicine, Pharmacy, Science and Technology of Târgu Mureș

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"MicroRNAs as Biomarkers and Therapeutic Targets in Heart Failure"}

Heart failure still represents a real challenge both in everyday practice and research, due to the complex issues related to its pathogenesis and management....

MicroRNAs as Biomarkers and Therapeutic Targets in Heart Failure

Published Online: Sep 26, 2019

Page range: 77 - 79

Received: Jun 07, 2019

Accepted: Jun 29, 2019

DOI: https://doi.org/10.2478/amma-2019-0016

Keywords
miRNA, biomarkers, heart failure

© 2019 István Adorján Szabó et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

MicroRNAs as Biomarkers and Therapeutic Targets in Heart Failure

Published Online: Sep 26, 2019

Page range: 77 - 79

Received: Jun 07, 2019

Accepted: Jun 29, 2019

DOI: https://doi.org/10.2478/amma-2019-0016

KeywordsmiRNA, biomarkers, heart failure

© 2019 István Adorján Szabó et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
miRNA, biomarkers, heart failure