<abstract xmlns="http://www.w3.org/1999/xhtml">Our <bold>objective</bold> was to investigate immunological changes that occur in saliva of subjects with type 2 diabetes mellitus (T2DM) without signs of periodontal disease and to establish if salivary inflammatory cytokines are a possible link between diabetes mellitus and periodontal breakdown.<bold>Material and methods</bold>. Twenty T2DM subjects with no periodontal disease and twenty healthy controls were registered for the present study. TNF-α and IL-6 level from saliva and serum were measured. Periodontal tissue samples were histologically examined.<bold>Results</bold>: TNF-α and IL-6 levels were higher in T2DM subjects compared to controls, with an extremely significant difference in saliva (p&lt;0.001). Significant inflammation, affecting both epithelial and connective tissues was present in periodontal biopsies.<bold>Conclusions</bold>: The subjects showed an increased TNF-α and IL-6 levels, both in serum and -mostly in -saliva of diabetics without signs of periodontal disease, confirming the hypothesis of immunological implication, as a correlation between periodontal disease incidence and diabetes mellitus. Histologic alterations, suggesting a local inflammatory state, were present in periodontal tissue of diabetics, confirming the above hypothesis. The study reveals that saliva analysis is a quite efficient method in testing the periodontal breakdown progression in the subjects with T2DM.</abstract>

Our objective was to investigate immunological changes that occur in saliva of subjects with type 2 diabetes mellitus (T2DM) without signs of periodontal disease and to establish if salivary inflammatory cytokines are a possible link between diabetes mellitus and periodontal breakdown.Material and methods. Twenty T2DM subjects with no periodontal disease and twenty healthy controls were registered for the present study. TNF-α and IL-6 level from saliva and serum were measured. Periodontal tissue samples were histologically examined.Results: TNF-α and IL-6 levels were higher in T2DM subjects compared to controls, with an extremely significant difference in saliva (p<0.001). Significant inflammation, affecting both epithelial and connective tissues was present in periodontal biopsies.Conclusions: The subjects showed an increased TNF-α and IL-6 levels, both in serum and -mostly in -saliva of diabetics without signs of periodontal disease, confirming the hypothesis of immunological implication, as a correlation between periodontal disease incidence and diabetes mellitus. Histologic alterations, suggesting a local inflammatory state, were present in periodontal tissue of diabetics, confirming the above hypothesis. The study reveals that saliva analysis is a quite efficient method in testing the periodontal breakdown progression in the subjects with T2DM.

Mediators of Inflammation as a Link Between Diabetes Mellitus and Periodontal Breakdown

University of medicine and pharmacy Tirgu-Mures

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Our objective was to investigate immunological changes that occur in saliva of subjects with type 2 diabetes mellitus (T2DM) without signs of periodontal...

Mediators of Inflammation as a Link Between Diabetes Mellitus and Periodontal Breakdown

Published Online: Mar 27, 2018

Page range: 39 - 45

Received: Jan 11, 2018

Accepted: Jan 29, 2018

DOI: https://doi.org/10.2478/amma-2018-0005

Keywords
diabetes mellitus, periodontal disease, TNF-α, Il-6, histopathology

© 2018 Adriana Monea et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mediators of Inflammation as a Link Between Diabetes Mellitus and Periodontal Breakdown

Published Online: Mar 27, 2018

Page range: 39 - 45

Received: Jan 11, 2018

Accepted: Jan 29, 2018

DOI: https://doi.org/10.2478/amma-2018-0005

Keywordsdiabetes mellitus, periodontal disease, TNF-α, Il-6, histopathology

© 2018 Adriana Monea et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
diabetes mellitus, periodontal disease, TNF-α, Il-6, histopathology