<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Nuclear protein in testis carcinoma is a very rare but extremely aggressive highgrade carcinoma characterized by the presence of a fusion NUT gene – an oncogene. It is also called midline carcinoma because it mainly affects structures along the midline – head, neck, and lungs. We report a case of a woman with lung nuclear protein in testis carcinoma, diagnosed by bronchoscopic fibro-punch biopsy. The histological examination showed massive infiltration of bronchial wall of predominantly spindle-shaped neoplastic cells with unclear cytoplasmic borders. In some areas groups of rounded cells with clearly visible nucleoli and high mitotic rate were present. Foci with necrosis were also found. Immuno-histochemistry showed positive expression of cytokeratin, p63, CD56 and nuclear protein in testis antibodies and negative reaction for TTF1 and chromogranin A in neoplastic cells. The proliferative activity of tumor cells was very high (> 70%). Immunohistochemical study of the nuclear protein in testis expression is mandatory in cases with poorly differentiated lung tumors, with predominantly midline mass.</p>
</abstract>

Nuclear protein in testis carcinoma is a very rare but extremely aggressive highgrade carcinoma characterized by the presence of a fusion NUT gene – an oncogene. It is also called midline carcinoma because it mainly affects structures along the midline – head, neck, and lungs. We report a case of a woman with lung nuclear protein in testis carcinoma, diagnosed by bronchoscopic fibro-punch biopsy. The histological examination showed massive infiltration of bronchial wall of predominantly spindle-shaped neoplastic cells with unclear cytoplasmic borders. In some areas groups of rounded cells with clearly visible nucleoli and high mitotic rate were present. Foci with necrosis were also found. Immuno-histochemistry showed positive expression of cytokeratin, p63, CD56 and nuclear protein in testis antibodies and negative reaction for TTF1 and chromogranin A in neoplastic cells. The proliferative activity of tumor cells was very high (> 70%). Immunohistochemical study of the nuclear protein in testis expression is mandatory in cases with poorly differentiated lung tumors, with predominantly midline mass.

A Rare Case of Lung Nuclear Protein in Testis Carcinoma

UMHAT “Sv. Iv. Rilski”, Medical University

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"A Rare Case of Lung Nuclear Protein in Testis Carcinoma"}

Nuclear protein in testis carcinoma is a very rare but extremely aggressive highgrade carcinoma characterized by the presence of a fusion NUT gene – an...

A Rare Case of Lung Nuclear Protein in Testis Carcinoma

Published Online: Jun 29, 2024

Page range: 8 - 11

Received: Feb 17, 2024

Accepted: Apr 26, 2024

DOI: https://doi.org/10.2478/amb-2024-0025

Keywords
nuclear protein in testis, midline carcinoma, lung tumor, lung, NUT gene

© 2024 S. Ivanova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

A Rare Case of Lung Nuclear Protein in Testis Carcinoma

Published Online: Jun 29, 2024

Page range: 8 - 11

Received: Feb 17, 2024

Accepted: Apr 26, 2024

DOI: https://doi.org/10.2478/amb-2024-0025

Keywordsnuclear protein in testis, midline carcinoma, lung tumor, lung, NUT gene

© 2024 S. Ivanova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
nuclear protein in testis, midline carcinoma, lung tumor, lung, NUT gene