<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Drug interactions with vitamin K antagonist may involve antiepileptic drug. Numerous antiepileptic drugs are strong inducers or inhibitors of liver enzymes and affect warfarin metabolism, including valproic acid, which is capable of displacing warfarin from the protein binding site. Although this type of drug interaction is less widely recognized, it is a phenomenon that causes significant changes in the INR. We report a case of severe subconjunctival bleeding in patient with concomitant use of warfarin and valproic acid. The management include cessation of the drug, conservative eye treatment, and vitamin K. The case was fully resolved.</p>
</abstract>

Drug interactions with vitamin K antagonist may involve antiepileptic drug. Numerous antiepileptic drugs are strong inducers or inhibitors of liver enzymes and affect warfarin metabolism, including valproic acid, which is capable of displacing warfarin from the protein binding site. Although this type of drug interaction is less widely recognized, it is a phenomenon that causes significant changes in the INR. We report a case of severe subconjunctival bleeding in patient with concomitant use of warfarin and valproic acid. The management include cessation of the drug, conservative eye treatment, and vitamin K. The case was fully resolved.

Severe Subconjunctival Bleeding in a Patient with Concomitant Use of Warfarin and Valproic Acid

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Drug interactions with vitamin K antagonist may involve antiepileptic drug. Numerous antiepileptic drugs are strong inducers or inhibitors of liver enzymes and...

Severe Subconjunctival Bleeding in a Patient with Concomitant Use of Warfarin and Valproic Acid

Published Online: Jun 29, 2024

Page range: 5 - 7

Received: Jan 26, 2024

Accepted: Apr 22, 2024

DOI: https://doi.org/10.2478/amb-2024-0024

Keywords
warfarin, divalproex acid, subconjunctival bleeding, stroke

© 2024 R. T. Pinzon et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Severe Subconjunctival Bleeding in a Patient with Concomitant Use of Warfarin and Valproic Acid

Published Online: Jun 29, 2024

Page range: 5 - 7

Received: Jan 26, 2024

Accepted: Apr 22, 2024

DOI: https://doi.org/10.2478/amb-2024-0024

Keywordswarfarin, divalproex acid, subconjunctival bleeding, stroke

© 2024 R. T. Pinzon et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
warfarin, divalproex acid, subconjunctival bleeding, stroke