<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>Cushing's Syndrome (CS) is the consequence of the exposure of tissues to extremely high levels of glucocorticoids. Early diagnosis and treatment are the mainstay of optimizing patient outcomes and improving their quality of life. In the recent years steroid profiling by LC-MS sheds more light on the diagnosis of CS.</p>
</sec>
<sec><h3>Materials and methods</h3>
<p>This was a retrospective cross-sectional study.</p>
</sec>
<sec><h3>Objective</h3>
<p>To investigate serum steroid precursor differences between different etiological forms of CS and to suggest a steroid panel for the diagnosis of MACS in patients with adrenal incidentalomas.</p>
</sec>
<sec><h3>Results</h3>
<p>Our studied patients with CD had significantly lower levels of 11-deoxycorticosterone (p = 0.047) and 17 OH progesterone (p = 0.024) compared to those with adrenal forms of CS. In out cohort of patients with adrenal incidentalomas, those with MACS had significantly lower levels of androgens (DHEA, p = 0.001) and cortisone (p = 0.015) and higher levels of 11-deoxycortisol (p = 0.039) compared to the patients with non-secreting adenomas (NSA). </p>
</sec>
<sec><h3>Conclusion</h3>
<p>Introducing LC-MS based steroid profiling would be very helpful in the diagnostic process of patients with CS.</p>
</sec>
</abstract>

Background
Cushing's Syndrome (CS) is the consequence of the exposure of tissues to extremely high levels of glucocorticoids. Early diagnosis and treatment are the mainstay of optimizing patient outcomes and improving their quality of life. In the recent years steroid profiling by LC-MS sheds more light on the diagnosis of CS.

Materials and methods
This was a retrospective cross-sectional study.

Objective
To investigate serum steroid precursor differences between different etiological forms of CS and to suggest a steroid panel for the diagnosis of MACS in patients with adrenal incidentalomas.

Results
Our studied patients with CD had significantly lower levels of 11-deoxycorticosterone (p = 0.047) and 17 OH progesterone (p = 0.024) compared to those with adrenal forms of CS. In out cohort of patients with adrenal incidentalomas, those with MACS had significantly lower levels of androgens (DHEA, p = 0.001) and cortisone (p = 0.015) and higher levels of 11-deoxycortisol (p = 0.039) compared to the patients with non-secreting adenomas (NSA). 

Conclusion
Introducing LC-MS based steroid profiling would be very helpful in the diagnostic process of patients with CS.

Steroid Profiling in the Differential Diagnosis of Cushing's Syndrome and Diagnosis of MACS

University Specialized Hospital for Active Treatment of Endocrinology

Central Laboratory of Therapeutic Drug Management and Clinical Pharmacology

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Background
Cushing's Syndrome (CS) is the consequence of the exposure of tissues to extremely high levels of glucocorticoids. Early diagnosis and treatment are...

Steroid Profiling in the Differential Diagnosis of Cushing's Syndrome and Diagnosis of MACS

Published Online: Jun 23, 2024

Page range: 1 - 7

Received: Oct 17, 2023

Accepted: Oct 23, 2023

DOI: https://doi.org/10.2478/amb-2024-0012

Keywords
Cushing's syndrome, adrenal incidentalomas, steroid profiling, mild autonomous cortisol secretion

© 2024 A. Nankova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Steroid Profiling in the Differential Diagnosis of Cushing's Syndrome and Diagnosis of MACS

Published Online: Jun 23, 2024

Page range: 1 - 7

Received: Oct 17, 2023

Accepted: Oct 23, 2023

DOI: https://doi.org/10.2478/amb-2024-0012

KeywordsCushing's syndrome, adrenal incidentalomas, steroid profiling, mild autonomous cortisol secretion

© 2024 A. Nankova et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Cushing's syndrome, adrenal incidentalomas, steroid profiling, mild autonomous cortisol secretion